The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction
The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction
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DOI：
10.1016/s0735-1097(99)00608-7
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发表时间：
2000-03-01
影响因子：
24
通讯作者：
Stevenson, LW
中科院分区：
文献类型：
--
作者：
Dries, DL;Exner, DV;Stevenson, LW
目的探讨中度肾功能不全对无症状和有症状的左心室收缩功能不全患者预后的影响。背景：慢性心内充盈压升高可能导致进行性的心室扩张和心力衰竭进展。维持液体平衡和防止心内充盈压升高的能力在很大程度上取决于肾功能的充分性。方法回顾分析左心功能不全(SOLVD)试验，其中中度肾功能不全被定义为基线肌酐清除
OBJECTIVES The present analysis examines the prognostic implications of moderate renal insufficiency in patients with asymptomatic and symptomatic:left ventricular systolic dysfunction.BACKGROUND Chronic elevations in intracardiac filling pressures may lead to progressive ventricular dilation and heart failure progression. The ability to maintain fluid balance and prevent increased intracardiac filling pressures is critically dependent on the adequacy of renal function.METHODS This is a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) Trials, in which moderate renal insufficiency is defined as a baseline creatinine clearance