Dopamine-β-hydroxylase in dog lymph - effect effect of sympathetic activation
Dopamine-β-hydroxylase in dog lymph - effect effect of sympathetic activation
复制标题
狗淋巴中的多巴胺-β-羟化酶-交感神经激活的作用
DOI：
10.1016/0024-3205(74)90139-8
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发表时间：
1974
期刊：
影响因子：
6.1
通讯作者：
S. Spector
中科院分区：
文献类型：
--
作者：
S. Ngai;W. Dairman;M. Marchelle;S. Spector
在麻醉狗中，压力感受器去神经和电刺激左星状神经节引起显著的动脉高压和心动过速。这些与胸导管淋巴液中多巴胺-β-羟化酶（DβH）的总输出量增加4-10倍有关。血清DβH活性低于人，交感神经兴奋过程中的变化不一致。这些结果表明，从肾上腺素能神经末梢释放的DβH的大部分在进入循环血液之前在淋巴中转运。
In anesthetized dogs baroreceptor denervation and electrical stimulation of the left stellate ganglion caused marked arterial hypertension and tachycardia. These were associated with a 4-10-fold increase in the total output of dopamine-β-hydroxylase (DβH) in the thoracic duct lymph. Serum DβH activity was lower than that in man and changes during sympathetic activation were inconsistent. These results suggest that a major portion of DβH released from adrenergic nerve terminals is transported in the lymph before it enters the circulating blood.