microRNA and Lung Cancer
microRNA and Lung Cancer
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DOI：
10.1007/978-3-319-23730-5_9
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发表时间：
2015-01-01
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影响因子：
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通讯作者：
Denti, Michela A.
中科院分区：
文献类型：
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作者：
Del Vescovo, Valerio;Denti, Michela A.
肺癌是全球癌症死亡的主要原因。microRNAs （miRNAs）在肺癌的发展、上皮-间质转化和治疗反应中发挥着重要作用。此外，在过去十年中，在切除的肿瘤样本或细针抽吸样本中测量的mirna已经成为肿瘤诊断、预后和预测治疗反应的令人信服的生物标志物，因为它们易于检测和具有极强的特异性。此外，在过去的5年里，人们越来越多地探索痰液、血浆、血清或全血中存在的mirna作为早期检测癌症的侵入性较小的生物标志物。
Lung cancer is the leading cause of cancer mortality worldwide. microRNAs (miRNAs) have been established as players with a relevant role in lung cancer development, epithelial-mesenchymal transition and response to therapy. Additionally, in the last decade, miRNAs, measured in resected tumor samples or in fine-needle aspirate samples have emerged as compelling biomarkers for tumor diagnosis, prognosis, and prediction of response to treatment, due to the ease of their detection and in their extreme specificity. Moreover, miRNAs present in sputum, in plasma, in serum or in whole-blood have increasingly been explored in the last 5 years as less invasive biomarkers for the early detection of cancers.