The effect of M1 muscarinic blockade on behavior and physiological responses following traumatic brain injury in the rat.
The effect of M1 muscarinic blockade on behavior and physiological responses following traumatic brain injury in the rat.
复制标题
M1 毒蕈碱阻断对大鼠脑外伤后行为和生理反应的影响。
DOI：
10.1016/0006-8993(90)90233-2
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发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Enters,EK
中科院分区：
文献类型：
--
作者：
Robinson,SE;Foxx,SD;Posner,MG;Martin,RM;Davis,TR;Guo,HZ;Enters,EK
Dicyclomine (1 mg/kg or 10 mg/kg), scopolamine (1 mg/kg), or saline was administered intraperitoneally ta rats 15 min prior to moderate fluid percussion brain injury. A variety of reflexes and responses were measured up to 60 min following injury, and body weight and several neurological measures were taken daily up to 10 days following injury. All 3 antimuscarinic treatments reduced the duration of transient behavioral suppression as assessed by these measures. It appears that blockade of the M1muscarinic receptor can attenuate transient behavioral suppression associated with concussive brain injury. Thus, stimulation of M1muscarinic receptors may mediate components of reversible traumatic unconsciousness following cerebral concussion. No differences were observed between saline and antimuscarinic treatments in the incidence of duration of apnea following injury. Scopolamine pretreatment significantly elevated heart rate prior to injury, but had no significant effect on the responses of heart rate and blood pressure to experimental concussion. Both doses of dicyclomine significantly reduced resting heart rate, but unlike scopolamine, significantly enhanced the cardiovascular response to fluid percussion injury. Antimuscarinic treatment significantly reduced body weight loss and certain motor deficits, including beam balance and beam walk performance, following concussive head injury. Scopolamine and both doses of dicyclomine appeared to be equally effective in reducing long-term deficits. Data from these experiments indicate that at least some of the long-term behavioral deficits following moderate levels of brain injury may involve the binding of acetylcholine to M1muscarinic receptors. These results suggest that M1muscarinic antagonists are of potential benefit in the treatment of at least moderate levels of head injury, and because of the lack of effects on heart rate and pupil diameter, may be superior to scopolamine.
