Defective interfering particles and virus evolution.
Defective interfering particles and virus evolution.
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DOI：
10.1016/0966-842x(93)90048-v
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发表时间：
1993-10-01
影响因子：
15.9
通讯作者：
Kirkwood, T B
中科院分区：
文献类型：
--
作者：
Bangham, C R;Kirkwood, T B
几乎所有的病毒都会产生复制缺陷突变体，对病毒在培养中的生长和进化产生复杂的影响。这些影响可以用一个简单的数学模型来定性地解释。然而，该模型表明，这些突变体的数量效应本质上是不可预测的。
Almost all viruses produce replication-defective mutants that have complex effects on the growth and evolution of the virus in culture. These effects can be explained qualitatively by a simple mathematical model. However, the model shows that the quantitative effects of these mutants are intrinsically unpredictable.