Chemical preparation of the eye in ophthalmic surgery. IV. Comparison of povidone-iodine on the conjunctiva with a prophylactic antibiotic.
Chemical preparation of the eye in ophthalmic surgery. IV. Comparison of povidone-iodine on the conjunctiva with a prophylactic antibiotic.
复制标题
眼科手术中眼睛的化学制剂。
DOI：
--
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
S. Khwarg
中科院分区：
文献类型：
--
作者：
S. Isenberg;L. Apt;R. Yoshimori;S. Khwarg
我们之前发现半浓度（5%）聚维酮碘溶液显着减少了结膜的细菌菌群。为了比较术前每天三次、持续三天的局部联合抗生素（新孢菌素眼用溶液）与作为术前准备的一部分给予的半强度聚维酮碘溶液的抗菌效果，对 35 名接受眼科手术的患者的结膜培养物进行了研究。当单独使用时，抗生素和聚维酮碘溶液会导致培养的细菌菌落数量和种类出现类似的大幅减少。当两种药物一起使用时，下降幅度更加惊人，使 83% 的结膜无菌。为了在眼科手术前最大限度地减少细菌菌群，我们建议在术前三天使用广谱局部抗生素，并在术前准备中使用半强度聚维酮碘溶液。
We previously found that half-strength (5%) povidone-iodine solution significantly reduced the bacterial flora of the conjunctiva. To compare the antibacterial effect of a topical combination antibiotic (Neosporin ophthalmic solution) given three times daily for three days preoperatively with that of half-strength povidone-iodine solution given as part of the preoperative preparation, conjunctival cultures were studied from 35 patients undergoing ocular surgery. When used individually, the antibiotic and povidone-iodine solutions caused a similar and substantial decrease in the number of colonies and species of bacteria cultured. When both drugs were used together, the decrease was even more striking, making 83% of the conjunctivae sterile. To minimize bacterial flora before ocular surgery, we recommend that a broad-spectrum topical antibiotic be given for three days preoperatively and that half-strength povidone-iodine solution be used as part of the preoperative preparation.