Diurnal mood variation in depression: A signal of disturbed circadian function?
Diurnal mood variation in depression: A signal of disturbed circadian function?
复制标题
DOI：
10.1016/j.jad.2006.12.001
复制
发表时间：
2007-09-01
影响因子：
6.6
通讯作者：
Murray, Greg
中科院分区：
文献类型：
--
作者：
Murray, Greg
背景资料：情绪的昼夜变化是抑郁症的一个突出症状，通常表现为积极的情绪变化（PM-V -情绪在醒来时更差，晚上更好）。本研究旨在通过测量具有不同程度抑郁情绪的非临床个体的日常情绪变化来促进对PMV的理解。基于对情绪的正常变化的研究和抑郁症的昼夜节律幅度可能降低的证据，假设与低水平抑郁症相比，符合流行病学中心抑郁量表（CES-D）可能抑郁症的截止值的个体在积极情绪（PA）的昼夜变化中表现出减弱的昼夜节律成分。方法：99名年轻健康女性（平均年龄= 21.5，标准差= 3.0）在正常的睡眠-觉醒时间表上生活，在0800 h和2200 h之间每两小时提供一次情绪报告，持续7天。高度抑郁组（CES-D >= 23，n = 22）表现出与PMV一致的昼夜变化模式（晚上PA相对于早上增加）。与预测的结果一致，高抑郁组与低抑郁组（CES-D < 23，n = 77）相比，PA昼夜变化的昼夜成分减少。结论：从昼夜功能减弱的角度理解抑郁症患者的昼夜情绪变化是有效的。研究结果进行了讨论的局限性，研究的自然主义设计和未来的研究途径确定。(c)2007 Elsevier B. V.保留所有权利。
Background: Diurnal variation in mood is a prominent symptom of depression, and is typically experienced as positive mood variation (PM-V - mood being worse upon waking and better in the evening). The present study sought to advance understanding of PMV by measuring daily mood variation in non-clinical individuals with varying levels of depressed mood. Based on research into normative variation in mood and evidence that circadian amplitudes may be decreased in depression, it was hypothesised that compared to those with low levels of depression, individuals meeting Centre for Epidemiological Studies-Depression Scale (CES-D) cut-off for probable depression would exhibit an attenuated circadian component in diurnal variation of Positive Affect (PA).Method: Ninety-nine young healthy women (mean age = 21.5, SD = 3.0) living on a normal sleep-wake schedule provided mood reports every two hours between 0800 h and 2200 h for 7 days.Results: The high depression group (CES-D >= 23, n = 22) exhibited a pattern of diurnal variation consistent with PMV (increased PA in the evening relative to the morning). As predicted, evidence was also found that the high depression group was characterized by a decreased circadian component to diurnal variation in PA relative to the low depression group (CES-D < 23, n = 77).Conclusions: It is provisionally concluded that diurnal mood variation in depression can usefully be understood from the perspective of weakened circadian function. Findings are discussed in terms of limitations of the study's naturalistic design and future research avenues identified. (c) 2007 Elsevier B.V. All rights reserved.