Expecting unpleasant stimuli - An fMRI study
Expecting unpleasant stimuli - An fMRI study
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DOI：
10.1016/j.pscychresns.2006.02.007
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发表时间：
2007-01-15
影响因子：
2.3
通讯作者：
Erk, Susanne
中科院分区：
文献类型：
--
作者：
Herwig, Uwe;Abler, Birgit;Erk, Susanne
预期即将发生的事件并准备好适当的反应是帮助个体处理环境的重要认知功能。一个事件的情感价值对结果行动是决定性的。揭示潜在的机制可能有助于理解抑郁症和焦虑症中与对未来的负面预期相关的信息处理功能障碍。我们对预期不愉快的视觉刺激时的选择性大脑活动感兴趣。在功能性磁共振成像过程中，12名健康女性受试者对情绪不愉快、愉快或中性刺激的预期和感知存在偏见。与预期的愉快刺激和中性刺激相比，预期不愉快的刺激会导致主要激活扣带回皮质、脑岛、前额叶、丘脑、下丘脑和纹状体。虽然某些区域在随后的情绪刺激呈现时也是活跃的，但在预期不愉快的刺激时，扣带回前部和丘脑的不同区域也是唯一活跃的。所确定的领域可反映内部适应和准备进程的网络，以便对预期的不愉快事件作出适当反应。众所周知，它们在抑郁时也会发生变化。这个网络的障碍可能与抑郁症等精神障碍有关。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Expecting forthcoming events and preparing adequate responses are important cognitive functions that help the individual to deal with the environment. The emotional valence of an event is decisive for the resulting action. Revealing the underlying mechanisms may help to understand the dysfunctional information processing in depression and anxiety that are associated with negative expectation of the future. We were interested in selective brain activity during the expectation of unpleasant visual stimuli. Twelve healthy female subjects were biased to expect and then perceive emotionally unpleasant, pleasant or neutral stimuli during functional magnetic resonance imaging. Expecting unpleasant stimuli relative to expecting pleasant and neutral stimuli resulted in activation of mainly cingulate cortex, insula, prefrontal areas, thalamus, hypothalamus and striatum. While certain areas were also active during subsequent presentation of the emotional stimuli, distinct regions of the anterior cingulate gyrus and the thalamus were solely active during expectation of the unpleasant stimuli. The identified areas may reflect a network for internal adaptation and preparation processes in order to react adequately to expected unpleasant events. They are known as well to be altered in depression. Disorders of this network may be relevant for psychiatric disorders such as depression. (c) 2006 Elsevier Ireland Ltd. All rights reserved.