Cardiac hypertrophy and performance of Dahl hypertensive rats on graded salt diets.
Cardiac hypertrophy and performance of Dahl hypertensive rats on graded salt diets.
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达尔高血压大鼠分级盐饮食的心脏肥大和表现。
DOI：
10.1161/01.hyp.6.4.475
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Iwai,J
中科院分区：
文献类型：
--
作者：
Pfeffer,MA;Pfeffer,J;Mirsky,I;Iwai,J
在Dahl抗性（R）和Dahl敏感性（S）高血压大鼠中评估了在心脏肥大的自然发展过程中动脉压与左心室（LV）功能容量和LV质量之间的关系，所述大鼠从5周龄至20周龄维持三种饮食NaCl方案（0.4%、4.0%和8.0%持续9周，然后4.0%）。在R大鼠中，动脉压和LV质量不受饮食的影响。与此相反，S大鼠表现出的动脉压和左心室肥大的水平，根据饮食氯化钠分级。乙醚麻醉下大鼠的血流动力学研究表明，S大鼠的分级压力升高是由相应的总外周阻力增加产生的，因为心输出量没有变化。在急性容量负荷期间，所有饮食的S大鼠达到了与R大鼠相同的最大每搏输出量，尽管S大鼠的动脉压显著增加。射血分数/后负荷关系的分析证明了保留的收缩状态。在S大鼠中，左心室产生压力的能力与左心室肥大的程度成正比。因此，在年轻的成年S大鼠，心脏的性能得到了很好的补偿，因为泵和收缩功能得到维持，压力产生能力增加的LV肥大的程度。
The relationship between arterial pressure and left ventricular (LV) functional capacity and LV mass during the natural development of cardiac hypertrophy was assessed in Dahl-resistant (R) and -sensitive (S) hypertensive rats maintained on three dietary NaCl regimens (0.4%, 4.0%, and 8.0% for 9 weeks, then 4.0%) from 5 until 20 weeks of age. In R rats, arterial pressure and LV mass were unaffected by diet. In contrast, S rats demonstrated levels of arterial pressure and LV hypertrophy that were graded according to dietary NaCl. Hemodynamic studies on rats under ether anesthesia demonstrated that the graded pressure elevation in S rats was produced by corresponding increases in total peripheral resistance, as cardiac output did not vary. During acute volume loading, the S rats on all diets achieved the same maximum stroke volume as did R rats, despite the marked increase in the arterial pressure of S rats. An analysis of the ejection fraction/afterload relationship demonstrated preserved contractile state. The ability of the left ventricle to generate pressure was increased in S rats in direct proportion to the degree of LV hypertrophy. Thus, in young adult S rats, cardiac performance was well compensated since pump and contractile functions were maintained and pressure-generating capacity was increased in relation to the degree of LV hypertrophy.