Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique.
Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique.
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DOI：
10.1007/s11095-010-0169-8
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发表时间：
2011-01
影响因子：
3.7
通讯作者：
Woolfson, A. David
中科院分区：
文献类型：
--
作者：
Donnelly, Ryan F.;Majithiya, Rita;Singh, Thakur Raghu Raj;Morrow, Desmond I. J.;Garland, Martin J.;Demir, Yusuf K.;Migalska, Katarzyna;Ryan, Elizabeth;Gillen, David;Scott, Christopher J.;Woolfson, A. David
设计和评估一种基于激光的新型方法，用于在环境条件下对聚合物材料进行微针阵列的微成型。本研究的目的是优化聚合物成分并评估具有不同几何形状的微针装置的性能。将一系列微针几何形状设计成有机硅微模具，随后表征了它们的物理化学特征。令人惊奇地发现，由粘膜粘附共聚物 Gantrez® AN-139 的 20% w/w 水性混合物微模塑而成的微针比常用的药物聚合物生产的微针具有更优异的物理强度。 Gantrez® AN-139 微针高度为 600 μm 和 900 μm，以低作用力（每根微针 >0.03 N）刺穿新生猪皮肤。当将茶碱装入 600 μm 微针时，83% 的药物在 24 小时内被递送到新生猪皮肤上。光学相干断层扫描（OCT）显示，无药物的600μm Gantrez® AN-139微针在体内刺穿了人体皮肤的角质层屏障，并延伸到皮肤内约460μm。然而，并未插入整个微针长度。在这项研究中，我们证明了一种新颖的激光工程方法可用于聚合物微针阵列的微成型。我们目前正在进行一项广泛的 OCT 信息研究，调查微针阵列几何形状对皮肤穿透深度的影响，以期增强优化的激光工程 Gantrez® AN-139 微针的透皮药物输送。
Design and evaluation of a novel laser-based method for micromoulding of microneedle arrays from polymeric materials under ambient conditions. The aim of this study was to optimise polymeric composition and assess the performance of microneedle devices that possess different geometries. A range of microneedle geometries was engineered into silicone micromoulds, and their physicochemical features were subsequently characterised. Microneedles micromoulded from 20% w/w aqueous blends of the mucoadhesive copolymer Gantrez® AN-139 were surprisingly found to possess superior physical strength than those produced from commonly used pharma polymers. Gantrez® AN-139 microneedles, 600 μm and 900 μm in height, penetrated neonatal porcine skin with low application forces (>0.03 N per microneedle). When theophylline was loaded into 600 μm microneedles, 83% of the incorporated drug was delivered across neonatal porcine skin over 24 h. Optical coherence tomography (OCT) showed that drug-free 600 μm Gantrez® AN-139 microneedles punctured the stratum corneum barrier of human skin in vivo and extended approximately 460 μm into the skin. However, the entirety of the microneedle lengths was not inserted. In this study, we have shown that a novel laser engineering method can be used in micromoulding of polymeric microneedle arrays. We are currently carrying out an extensive OCT-informed study investigating the influence of microneedle array geometry on skin penetration depth, with a view to enhanced transdermal drug delivery from optimised laser-engineered Gantrez® AN-139 microneedles.
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影响因子：
3.4
作者：
Donnelly RF;Morrow DI;Singh TR;Migalska K;McCarron PA;O'Mahony C;Woolfson AD
通讯作者：
Woolfson AD
DOI：
10.1073/pnas.2331316100
发表时间：
2003-11-25
影响因子：
11.1
作者：
McAllister, DV;Wang, PM;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
2.8
作者：
Haq, M. I.;Smith, E.;Birchall, J. C.
通讯作者：
Birchall, J. C.
影响因子：
5.7
作者：
Kaushik, S;Hord, AH;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
10.8
作者：
Donnelly, Ryan F.;Morrow, Desmond I. J.;Moan, Johan
通讯作者：
Moan, Johan