The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials
The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials
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补充益生元或益生菌对流感疫苗接种后抗体滴度的影响：随机对照试验的系统评价和荟萃分析
DOI：
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
C. Lin
中科院分区：
文献类型：
--
作者：
Tzu;Pei;Shu;Chao;Jui;Wei‐Te Lei;C. Lin
研究背景流感是一种常见病，给人类带来巨大的疾病负担。流感疫苗接种已被广泛使用，但对疫苗有效性的担忧仍然存在，特别是在老年人中。益生菌是具有免疫调节作用的活微生物，可增强对流感疫苗接种的免疫应答。方法我们进行了系统回顾和荟萃分析，以确定益生元/益生菌/合生元补充剂对流感疫苗接种反应的影响。截至2017年7月，从电子数据库中系统识别研究。提取并分析了关于研究人群、流感疫苗接种、补充剂组分和免疫应答的信息。本综述纳入了12项研究，共调查了688名参与者。结果发现使用益生元/益生菌补充剂的患者在接种疫苗后流感血凝抑制抗体滴度较高（甲型H1N1流感病毒感染者为42.89 vs 35.76，均数差=7.14，95% CI =2.73，11.55，P=0.002; A/H3 N2为105.4vs88.25，平均差异=17.19，95%CI =3.39，30.99，P=0.01; B株为34.87vs30.73，平均差异=4.17，95%CI =0.37，7.96，P=0.03）。结论添加益生元或益生菌可提高甲型H1 N1、甲型H3 N2和B流感病毒血凝抑制抗体滴度，分别提高20%、19.5%和13.6%。伴随益生元或益生菌补充流感疫苗接种可能有很大的希望，以提高疫苗的效力。然而，观察到高度异质性，需要进一步研究。
Background Influenza infection is a common disease with a huge disease burden. Influenza vaccination has been widely used, but concerns regarding vaccine efficacy exist, especially in the elderly. Probiotics are live microorganisms with immunomodulatory effects and may enhance the immune responses to influenza vaccination. Methods We conducted a systematic review and meta-analysis to determine the influence of prebiotics/probiotics/synbiotics supplementation on vaccine responses to influenza vaccination. Studies were systematically identified from electronic databases up to July 2017. Information regarding study population, influenza vaccination, components of supplements, and immune responses were extracted and analyzed. Twelve studies, investigating a total of 688 participants, were included in this review. Results Patients with prebiotics/probiotics supplements were found to have higher influenza hemagglutination inhibition antibody titers after vaccination (for A/H1N1, 42.89 vs 35.76, mean difference =7.14, 95% CI =2.73, 11.55, P=0.002; for A/H3N2, 105.4 vs 88.25, mean difference =17.19, 95% CI =3.39, 30.99, P=0.01; for B strain, 34.87 vs 30.73, mean difference =4.17, 95% CI =0.37, 7.96, P=0.03). Conclusion Supplementation with prebiotics or probiotics may enhance the influenza hemagglutination inhibition antibody titers in all A/H1N1, A/H3N2, and B strains (20%, 19.5%, and 13.6% increases, respectively). Concomitant prebiotics or probiotics supplementation with influenza vaccination may hold great promise for improving vaccine efficacy. However, high heterogeneity was observed and further studies are warranted.
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影响因子：
16.8
作者：
Chen WH;Kozlovsky BF;Effros RB;Grubeck-Loebenstein B;Edelman R;Sztein MB
通讯作者：
Sztein MB
影响因子：
26.1
作者：
Chang, Yung-Sen;Trivedi, Michelle K.;Garcia-Romero, Maria T.
通讯作者：
Garcia-Romero, Maria T.
影响因子：
2.9
作者：
Floch, Martin H.;Walker, W. Allan;Brandt, Lawrence J.
通讯作者：
Brandt, Lawrence J.
DOI：
10.1073/pnas.1518189113
发表时间：
2016-03-01
影响因子：
11.1
作者：
Li, Jun;Sung, Cecilia Ying Ju;El-Nezami, Hani
通讯作者：
El-Nezami, Hani
新型三价灭活流感疫苗的免疫原性、安全性和一致性。
影响因子：
5.5
作者：
Talbot,HKeipp;Keitel,Wendy;Cate,ThomasR;Treanor,John;Campbell,James;Brady,RebeccaC;Graham,Irene;Dekker,CorneliaL;Ho,Dora;Winokur,Patricia;Walter,Emmanuel;Bennet,Jillian;Formica,Neil;Hartel,Gunter;Skeljo,Maryanne;Edwards,
通讯作者：
Edwards,