Effects of smoking abstinence on visuospatial working memory function in schizophrenia
Effects of smoking abstinence on visuospatial working memory function in schizophrenia
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DOI：
10.1016/s0893-133x(01)00296-2
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发表时间：
2002-01-01
影响因子：
7.6
通讯作者：
Wexler, BE
中科院分区：
文献类型：
--
作者：
George, TP;Vessicchio, JC;Wexler, BE
精神分裂症患者的认知功能受损，包括视觉空间工作记忆（VSWM）的缺陷。VSWM部分由前额叶皮质多巴胺（DA）功能介导，并且前额叶皮质DA系统的失调可能有助于精神分裂症的病理生理学。在动物研究中，尼古丁对空间工作记忆（SWM）有复杂的影响，大多数研究表明SWM增强。吸烟在精神分裂症中非常普遍，这些患者可能会吸烟来弥补认知缺陷。本研究探讨了急性（
Schizophrenic patients have impairments in cognitive function, including deficits in visuospatial working memory (VSWM). VSWM is mediated, in part, by prefrontal cortical dopamine (DA)function, and dysregulation of prefrontal cortical DA systems may contribute to the pathophysiology of schizophrenia. Nicotine has complex effects on spatial working memory (SWM) in animal studies, with most studies demonstrating enhancement of SWM. Cigarette smoking is highly prevalent in schizophrenia, and these patients may smoke cigarettes to remediate cognitive deficits. The present study examined the effects of acute (