In vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin, and four other antimicrobials against intestinal anaerobic bacteria
In vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, bacitracin, and four other antimicrobials against intestinal anaerobic bacteria
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DOI：
10.1128/aac.47.7.2334-2338.2003
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发表时间：
2003-07-01
影响因子：
4.9
通讯作者：
Goldstein, EJC
中科院分区：
文献类型：
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作者：
Citron, DM;Merriam, CV;Goldstein, EJC
通过使用琼脂稀释法，测定了雷莫拉宁、替考拉宁、万古霉素、利奈唑胺和其他5种药物对300株革兰氏阳性和54株革兰氏阴性肠道厌氧菌菌株的体外活性。2 μ g/ml雷莫拉宁对300种革兰氏阳性微生物中的287种（95.7%）具有活性，包括18种艰难梭菌菌株，雷莫拉宁的MIC为0.25 - 0.5 μ g/ml;其中3种，利奈唑胺的MIC为8 - 16 μ g/ml。19株无害梭菌菌株对万古霉素MIC（90%的菌株被抑制）为16 μ g/ml，对0.06 - 0.25 μ g/ml雷莫拉宁和0.125 - 1.0 μ g/ml替考拉宁敏感。真杆菌属、放线菌属、丙酸杆菌属和消化链霉菌属的所有菌株。被小于或等于0.25 μ g/ml的雷莫拉宁和小于或等于1 μ g/ml的万古霉素抑制。雷莫拉宁在小于或等于4 μ g/ml的浓度下对22种测试的普雷沃菌属和卟啉单胞菌属菌株中的15种也有活性，但雷莫拉宁对脆弱拟杆菌群、死亡梭杆菌-变异梭杆菌群和韦荣氏球菌属的所有31种菌株的MIC均小于或等于4 μ g/ml。大于或等于256 μ g/ml。雷莫拉宁对C.艰难梭菌和其他革兰氏阳性肠道厌氧菌，包括万古霉素耐药菌株;然而，它对大多数革兰氏阴性厌氧菌的活性很差，因此对正常粪便植物群的生态平衡的影响可能较小。
By using an agar dilution method, the in vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, and five other agents were determined against 300 gram-positive and 54 gram-negative strains of intestinal anaerobes. Ramoplanin was active at 2 mug/ml against 287 of 300 (95.7%) gram-positive organisms, including 18 strains of Clostridium difficile for which MICs of ramoplanin were 0.25 to 0.5 mug/ml; for 3 of these, linezolid MICs were 8 to 16 mug/ml. Nineteen Clostridium innocuum strains for which the vancomycin MIC at which 90% of strains were inhibited was 16 mug/ml were susceptible to ramoplanin at 0.06 to 0.25 mug/ml and to teicoplanin at 0.125 to 1.0 mug/ml. All strains of Eubacterium, Actinomyces, Propionibacterium, and Peptostreptococcus spp. were inhibited by less than or equal to0.25 mug of ramoplanin per ml and less than or equal to1 mug of vancomycin per ml. Ramoplanin was also active at less than or equal to4 mug/ml against 15 of 22 of the Prevotella and Porphyromonas strains tested, but ramoplanin MICs for all 31 strains of the Bacteroides fragilis group, the Fusobacterium mortiferum-Fusobacterium varium group, and Veillonella spp. were greater than or equal to256 mug/ml. Ramoplanin displays excellent activity against C. difficile and other gram-positive enteric anaerobes, including vancomycin-resistant strains; however, it has poor activity against most gram-negative anaerobes and thus potentially has a lesser effect on the ecological balance of normal fecal flora.