Predictors of infection, symptoms development, and mortality in people with SARS-CoV-2 living in retirement nursing homes.
Predictors of infection, symptoms development, and mortality in people with SARS-CoV-2 living in retirement nursing homes.
复制标题
居住在养老院的SARS-CoV-2感染者的感染、症状发展和死亡率的预测因素
DOI：
10.1371/journal.pone.0248009
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Babudieri S
中科院分区：
文献类型：
--
作者：
De Vito A;Fiore V;Princic E;Geremia N;Panu Napodano CM;Muredda AA;Maida I;Madeddu G;Babudieri S
自大流行病开始以来，已有数百万人受到感染，数千人死亡。全世界范围内的许多病灶都是在退休疗养院发现的，死亡人数很高。我们的研究目的是评估SARS-CoV-2在养老院的传播，发展症状和死亡的预测因素。我们进行了一项回顾性研究，招募了所有居住在退休疗养院（PLRNH）的人，其中至少有一名SARS-CoV-2感染者。收集了医疗和临床数据。适当时，使用Student t检验或Pearson卡方检验对变量进行比较。进行单因素和多因素分析，以评估变量对感染和症状发展的影响。采用考克斯比例风险模型评价30天死亡率的预测因素，将死亡作为因变量。我们招募了382名受试者。平均年龄为81.15±10.97岁，男性140例（36.7%）。在多变量分析中，精神障碍、恶性肿瘤和血管紧张素II受体阻滞剂是SARS-CoV-2感染的预测因子，而神经系统综合征与较低的风险相关。只有一半的SARS-CoV-2感染者出现症状。慢性阻塞性肺疾病和神经系统综合征与SARS-CoV-2相关症状风险增加相关。五十六（21.2%）例SARS-CoV-2感染者死亡;其中53例在拭子阳性后的前30天内死亡。与30天死亡率相关的重要因素是男性、运动功能减退疾病、发热和呼吸困难。患者的自主性和早期肝素治疗与较低的死亡风险有关。我们证明了在死亡率高的环境中，如退休疗养院，感染的风险和死亡的相关因素，这应该在PLRNH的管理中仔细考虑。
Since the start of the pandemic, millions of people have been infected, with thousands of deaths. Many foci worldwide have been identified in retirement nursing homes, with a high number of deaths. Our study aims were to evaluate the spread of SARS-CoV-2 in the retirement nursing homes, the predictors to develop symptoms, and death. We conducted a retrospective study enrolling all people living in retirement nursing homes (PLRNH), where at least one SARS-CoV-2 infected person was present. Medical and clinical data were collected. Variables were compared with Student’s t-test or Pearson chi-square test as appropriate. Uni- and multivariate analyses were conducted to evaluate variables’ influence on infection and symptoms development. Cox proportional-hazards model was used to evaluate 30 days mortality predictors, considering death as the dependent variable. We enrolled 382 subjects. The mean age was 81.15±10.97 years, and males were 140(36.7%). At the multivariate analysis, mental disorders, malignancies, and angiotensin II receptor blockers were predictors of SARS-CoV-2 infection while having a neurological syndrome was associated with a lower risk. Only half of the people with SARS-CoV-2 infection developed symptoms. Chronic obstructive pulmonary disease and neurological syndrome were correlated with an increased risk of developing SARS-CoV-2 related symptoms. Fifty-six (21.2%) people with SARS-CoV-2 infection died; of these, 53 died in the first 30 days after the swab’s positivity. Significant factors associated with 30-days mortality were male gender, hypokinetic disease, and the presence of fever and dyspnea. Patients’ autonomy and early heparin treatment were related to lower mortality risk. We evidenced factors associated with infection’s risk and death in a setting with high mortality such as retirement nursing homes, that should be carefully considered in the management of PLRNH.
登录
查看更多内容
影响因子：
1.6
作者：
Johnson, HD;Sholcosky, D;Ogonosky, N
通讯作者：
Ogonosky, N
影响因子：
--
作者：
Khan, Sikandar Hayat;Zaidi, Sabeen Khurshid
通讯作者：
Zaidi, Sabeen Khurshid
中国湖南省老年 COVID-19 患者的临床特征：一项多中心回顾性研究
影响因子：
3.5
作者：
Guo, Ting;Shen, Qinxue;Peng, Hong
通讯作者：
Peng, Hong
影响因子：
33.9
作者：
Kimball, Anne;Hatfield, Kelly M.;Jernigan, John A.
通讯作者：
Jernigan, John A.
影响因子：
120.7
作者：
Fosbol, Emil L.;Butt, Jawad H.;Kober, Lars
通讯作者：
Kober, Lars