Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes.
Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes.
复制标题
双-[4-甲氧基-3-(6-芳基-7H-[1,2,4]三唑并[3,4-b][1,3,4]-噻二嗪-3-基)的合成及抗菌活性
作者：
A. Srinivas
一系列新型双-[4-甲氧基-3-(6-芳基-7H-[1,2,4]三唑[3,4-b][1,3,4]-噻二嗪-3-基)苯基]甲烷和双-[(三唑并[3,4-b]噻二嗪-3-基)苯基]甲烷( 5a-e & 6a-e ) 合成并通过IR、(1)H NMR、(13)C NMR、MS和元素分析表征。筛选了所有新合成的化合物对枯草芽孢杆菌、金黄色葡萄球菌、产气克罗布辛氏菌和紫色色杆菌的抗菌活性，以及对白色念珠菌、烟曲霉、红色毛癣菌和须毛癣菌的抗真菌活性。化合物5b、5d、5e、6b、6c和6e对测试细菌和真菌表现出有效的活性，并成为进一步开发的潜在分子。
A series of novel Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]tria zolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes ( 5a-e & 6a-e ) has been synthesized and characterized by IR, (1)H NMR, (13)C NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacteriumviolaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d,5e, 6b, 6c and 6e exhibited potent activity against the test bacteria and fungi, and emerged as potential molecules for further development.