A 16-channel 1.1mm2 implantable seizure control SoC with sub-μW/channel consumption and closed-loop stimulation in 0.18µm CMOS
A 16-channel 1.1mm2 implantable seizure control SoC with sub-μW/channel consumption and closed-loop stimulation in 0.18µm CMOS
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16 通道 1.1mm2 植入式癫痫控制 SoC，具有低于 μW/通道的功耗和 0.18μm CMOS 中的闭环刺激
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发表时间：
2016
期刊：
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通讯作者：
A. Emami
中科院分区：
文献类型：
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作者：
Mahsa Shoaran;Masoud Shahshahani;Masoud Farivar;J. Almajano;Amirhossein Shahshahani;A. Schmid;A. Bragin;Y. Leblebici;A. Emami
我们提出了一个16通道癫痫发作检测系统芯片（SoC），在总面积为1.1mm 2，包括一个闭环神经刺激器，0.92μW/通道功耗。从空间滤波的神经数据中提取一组四个特征，以最小的硬件成本实现高检测精度。通过在自由活动大鼠中早期检测和终止红藻氨酸诱导的癫痫发作以及通过对人类颅内EEG（iEEG）数据的离线评估来证明性能。我们的设计改进了以前的作品，每通道的功率面积产品减少了40倍以上。这一改进是集成具有更高时空分辨率的更大阵列以进一步提高检测精度的关键一步。
We present a 16-channel seizure detection system-on-chip (SoC) with 0.92μW/channel power dissipation in a total area of 1.1mm2 including a closed-loop neural stimulator. A set of four features are extracted from the spatially filtered neural data to achieve a high detection accuracy at minimal hardware cost. The performance is demonstrated by early detection and termination of kainic acid-induced seizures in freely moving rats and by offline evaluation on human intracranial EEG (iEEG) data. Our design improves upon previous works by over 40× reduction in power-area product per channel. This improvement is a key step towards integration of larger arrays with higher spatiotemporal resolution to further boost the detection accuracy.