Clinical Features and Prognostic Factors of Anaerobic Infections: A 7-Year Retrospective Study
Clinical Features and Prognostic Factors of Anaerobic Infections: A 7-Year Retrospective Study
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DOI：
10.3904/kjim.2009.24.1.13
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发表时间：
2009-03-01
影响因子：
2.4
通讯作者：
Kim, June Myung
中科院分区：
文献类型：
--
作者：
Park, Yoonseon;Choi, Jun Young;Kim, June Myung
Background/Aims: Risk factors for mortality resulting from anaerobic infection are incompletely defined. The clinical significance of a broad range of pathogenic obligate anaerobic organisms was examined, and factors independently associated with mortality were identified in patients with clinically significant anaerobic infections.Methods: The medical records of 1,050 patients with anaerobic infections were retrospectively reviewed at Severance Hospital in Seoul, Korea.Results: The mean age of the patients was 54.1 +/- 16.8 years, and 57.7% were men. Overall, 320 (30.5%) patients with case-defined illness experienced pain at the affected site, and 230 (21.9%) experienced pus flow from lesions. Ten (1.4%) patients presented with shock, and 80.3% of the clinically significant cases were polymicrobial anaerobic infections. The mean number of pathogens, including aerobic and anaerobic bacteria, was 3.7 +/- 1.0 (minimum 1, maximum 5), and the number of anaerobic organisms was 1.0 +/- 0.3 in each specimen. The major pathogens by rank were the Bacteroides fragilis group, which accounted for 41.8% of anaerobic infections, followed by Clostridium spp. (11.8%), Prevotella spp. (9.4%), and Peptostreptococcus spp. (8.4%). Escherichia coli (17.5%), Staphylococcus aureus (7.5%), and Klebsiella pneumoniae (7.5%) were common concomitant aerobic organisms. The overall crude mortality rate resulting from anaerobic infection was 29.7%. Among the determining factors associated with mortality, liver disease (p=0.003) and old age (p=0.005) were significant in multivariate analysis.Conclusions: Anaerobic infection is polymicrobial and has a significant role in morbidity and mortality. Underlying liver disease was associated with poor prognosis in anaerobic infection. (Korean J Intern Med 2009;24:13-18)
