Outer retinal tubulation in the comparison of age-related macular degeneration treatments trials (CATT).
Outer retinal tubulation in the comparison of age-related macular degeneration treatments trials (CATT).
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DOI：
10.1016/j.ophtha.2014.06.013
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发表时间：
2014-12
期刊：
影响因子：
13.7
通讯作者：
CATT Research Group
中科院分区：
文献类型：
--
作者：
Lee JY;Folgar FA;Maguire MG;Ying GS;Toth CA;Martin DF;Jaffe GJ;CATT Research Group
To determine the prevalence of, risk factors for, and visual acuity correlations with outer retinal tubulation (ORT) seen on spectral domain optical coherence tomography (SD-OCT) in eyes with neovascular age-related macular degeneration (AMD) following anti-VEGF therapy. Prospective cohort study within a randomized clinical trial. Patients with SD-OCT images at Week 56 and 104 in the Comparison of AMD Treatment Trials (CATT). Participants in the CATT were randomly assigned to ranibizumab (0.5mg) or bevacizumab (1.25mg) treatment and to a monthly or PRN injection-dosing regimen. A subset of eyes were imaged with SD-OCT beginning at Week 56. Cirrus 512×128 or Spectralis 20°×20° volume cube scan protocols were used to acquire SD-OCT images. Two independent readers at the CATT OCT Reading Center graded scans, and a senior reader arbitrated discrepant grades. The prevalence of ORT, identified as a tubular structures seen on at least 3 consecutive Cirrus B scans or 2 consecutive Spectralis B scans, was determined. The associations of patient-specific and ocular features at baseline and follow-up with ORT were evaluated by univariate and multivariate analyses. Outer retinal tubulations. Seven of 69 eyes (10.1%) at 56 weeks and 64 of 368 (17.4%) eyes at week 104 had ORTs. Absence of diabetes, poor visual acuity (VA), blocked fluorescence, geographic atrophy (GA), greater lesion size, and presence of subretinal hyper-reflective material at baseline were independently associated with greater risk of ORT at 104 weeks (p<0.05). Neither drug nor dosing regimen were significantly associated with ORT. The mean VA of eyes with ORT at week 104 (58.5 ETDRS letters) was worse than the mean VA of eyes without ORT (68.8 letters; p<0.0001). At 2 years after initiation of anti-VEGF therapy for neovascular AMD, ORTs are present in a substantial proportion of eyes. We have identified baseline features that independently predict ORTs. It is important to identify ORTs, since eyes with ORTs have worse visual acuity outcomes than those without this finding.
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影响因子：
--
作者：
Zweifel, Sandrine A.;Engelbert, Michael;Freund, K. Bailey
通讯作者：
Freund, K. Bailey
影响因子：
13.7
作者：
Ying GS;Huang J;Maguire MG;Jaffe GJ;Grunwald JE;Toth C;Daniel E;Klein M;Pieramici D;Wells J;Martin DF;Comparison of Age-related Macular Degeneration Treatments Trials Research Group
通讯作者：
Comparison of Age-related Macular Degeneration Treatments Trials Research Group
影响因子：
3.9
作者：
Ellabban, A. A.;Hangai, M.;Yoshimura, N.
通讯作者：
Yoshimura, N.
影响因子：
13.7
作者：
DeCroos FC;Toth CA;Stinnett SS;Heydary CS;Burns R;Jaffe GJ;CATT Research Group
通讯作者：
CATT Research Group
DOI：
10.1056/nejmoa1102673
发表时间：
2011-05-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
CATT Research Group;Martin DF;Maguire MG;Ying GS;Grunwald JE;Fine SL;Jaffe GJ
通讯作者：
Jaffe GJ