Familial relationship between mood disorders and alcoholism
Familial relationship between mood disorders and alcoholism
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DOI：
10.1053/comp.2001.21221
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发表时间：
2001-03-01
影响因子：
7.3
通讯作者：
Merikangas, KR
中科院分区：
文献类型：
--
作者：
Preisig, M;Fenton, BT;Merikangas, KR
临床和流行病学研究一致揭示了酒精使用障碍与双相和非双相心境障碍之间的关联。然而，关于这些关联性质的证据尚不清楚。酒精和情感障碍的家族模式进行了检查，使用的数据从一个对照的家庭研究的先证者与酒精和焦虑症谁是从治疗环境和社区抽样。先证者中心境和焦虑障碍的共病程度很高，这使得我们可以对酒精和心境障碍的共病和家族聚集性进行研究。主要发现：（1）酒精中毒与亲属中的双相和非双相心境障碍有关;（2）酒精依赖有很强的家族聚集性，两种类型的心境障碍都有。和（3）没有交叉聚集的证据（即，酒精依赖先证者的情绪障碍增加，反之亦然）酒精中毒和情绪障碍之间。双相情感障碍和酒精中毒的独立聚集以及双相情感障碍的发作倾向于先于酒精中毒的发现与自我药疗假说相一致，这是这些疾病频繁共同发生的解释。相反，独立的家族聚集性和酒精中毒比非双相抑郁症更早发病的趋势表明，单极心境障碍往往继发于酒精中毒。Copyright（C）2001 by W.B.桑德斯公司
Clinical and epidemiological studies have consistently revealed an association between alcohol use disorders and both bipolar and nonbipolar mood disorders. However, the evidence regarding the nature of these associations is unclear. The familial patterns of alcohol and affective disorders were examined using data from a controlled family study of probands with alcohol and anxiety disorders who were sampled from treatment settings and the community. The substantial degree of comorbidity between mood and anxiety disorders among probands allowed for the examination of comorbidity and familial aggregation of alcohol and mood disorders, The major findings are that (1) alcoholism was associated with bipolar and nonbipolar mood disorders in the relatives; (2) there was a strong degree of familial aggregation of alcohol dependence and both types of mood disorders were observed; and (3) there was no evidence of cross-aggregation (i.e., increase in mood disorders among probands with alcohol dependence, and vice versa) between alcoholism and mood disorders. The independent familiar aggregation of bipolar disorder and alcoholism and the finding that the onset of bipolar disorder tended to precede that of alcoholism are compatible with a self-medication hypothesis as the explanation for the frequent co-occurrence of these disorders. In contrast, the independent familial aggregation and the tendency of an earlier onset of alcoholism than that of nonbipolar depression suggest that unipolar mood disorders are frequently secondary to alcoholism. Copyright (C) 2001 by W.B. Saunders Company.