DIFFERENTIAL INHIBITION OF RAT AND HUMAN GLUTATHIONE-S-TRANSFERASE ISOENZYMES BY PLANT PHENOLS
DIFFERENTIAL INHIBITION OF RAT AND HUMAN GLUTATHIONE-S-TRANSFERASE ISOENZYMES BY PLANT PHENOLS
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DOI：
10.1016/s0006-291x(86)80167-x
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发表时间：
1986-12-30
影响因子：
3.1
通讯作者：
AWASTHI, YC
中科院分区：
文献类型：
--
作者：
DAS, M;SINGH, SV;AWASTHI, YC
从人体组织和大鼠肝脏中分离得到的谷胱甘肽S转移酶同工酶分别被槲皮素、茜素、紫葛根素和鞣花酸抑制。与人类GST同工酶相比，大鼠肝脏GST同工酶对这些化合物的敏感性要高得多。在人类GST中，含有C型和A‘’型亚基的阴离子同工酶比含有A型和B型亚基的阳离子同工酶受到更大程度的抑制。这些植物酚对人红细胞和胎盘的阴离子GST同工酶有不同程度的抑制作用，提示胎盘和红细胞的同工酶可能是不同的蛋白质。
Glutathione S-transferase (GST) isoenzymes isolated from human tissues and rat liver are differentially inhibited by quercetin, alizarin, purpurogallin and ellagic acid. Rat liver GST isoenzymes are far more sensitive to these compounds as compared to the human GST isoenzymes. Among human GST, the anionic isoenzymes containing C type and A'' type subunits are inhibited to a greater extent as compared to the cationic isoenzymes containing A and B type subunits. The anionic GST isoenzymes of human erythrocytes and placenta are differentially inhibited by these plant phenols indicating that the placental and erythrocyte isoenzymes may be distinct proteins.