LncRNA NBR2 suppresses migration and invasion of colorectal cancer cells by downregulating miRNA-21
LncRNA NBR2 suppresses migration and invasion of colorectal cancer cells by downregulating miRNA-21
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DOI：
10.1007/s13577-019-00265-1
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发表时间：
2019-10-01
期刊：
影响因子：
4.3
通讯作者：
Zhang, Rui
中科院分区：
文献类型：
--
作者：
Bai, Jinghui;Xu, Jian;Zhang, Rui
据报道，lncRNA NBR 2调节癌症代谢。我们研究了NBR 2在结直肠癌中的作用。我们发现，NBR 2在结直肠癌组织中的表达低于邻近的健康组织。随着临床分期的增加，NBR 2在肿瘤组织中的表达水平逐渐降低。miRNA-21在结直肠癌组织中比在邻近的健康组织中上调，并且与NBR 2显著负相关。NBR 2过表达下调了结直肠癌细胞中的miRNA-21，而miRNA-21过表达未能显著影响NBR 2的表达。NBR 2过表达抑制结直肠癌细胞的迁移和侵袭。miRNA-21过表达发挥相反的作用，减弱了NBR 2过表达的影响。NBR 2过表达没有显著改变癌细胞增殖。因此，lncRNA NBR 2可能通过下调miRNA-21抑制结直肠癌细胞的迁移和侵袭。
It has been reported that lncRNA NBR2 regulates cancer metabolism. We investigated the role of NBR2 in colorectal cancer. We found that NBR2 was downregulated in colorectal cancer tissues than in adjacent healthy tissues. Decreased expression levels of NBR2 in tumor tissues were observed with the increase of clinical stages. MiRNA-21 was upregulated in colorectal cancer tissues than in adjacent healthy tissues, and was significantly and inversely correlated with NBR2. NBR2 overexpression downregulated miRNA-21 in colorectal cancer cells, while miRNA-21 overexpression failed to significantly affect NBR2 expression. NBR2 overexpression suppressed migration and invasion of colorectal cancer cells. MiRNA-21 overexpression played an opposite role and attenuated the effects of NBR2 overexpression. NBR2 overexpression did not significantly alter cancer cell proliferation. Therefore, lncRNA NBR2 inhibited colorectal cancer cell migration and invasion possibly by downregulating miRNA-21.