Spiking in primary somatosensory cortex during natural whisking in awake head-restrained rats is cell-type specific
Spiking in primary somatosensory cortex during natural whisking in awake head-restrained rats is cell-type specific
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DOI：
10.1073/pnas.0904143106
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发表时间：
2009-09-22
影响因子：
11.1
通讯作者：
Sakmann, Bert
中科院分区：
文献类型：
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作者：
de Kock, Christiaan P. J.;Sakmann, Bert
感觉涉及感觉器官的主动运动，但感觉器官的位置或运动如何在皮层中编码仍然未知。在大鼠须系统中，每个须由单独的皮质（桶）列表示。在这里，我们量化了清醒的，头部固定的大鼠的影响，自然的胡须运动对动作电位频率的单个（确定）神经元位于不同层的体感（桶）皮层。在所有层中，我们发现尖峰与须状物位置或速度之间仅存在较弱的相关性。相反，搅拌显着增加尖峰速率在一个子集的神经元位于优先在层5A。这一发现表明，胡须运动可能是由所有层内的神经元的群体反应和层5A中的单个细长簇状金字塔编码的。
Sensation involves active movement of sensory organs, but it remains unknown how position or movement of sensory organs is encoded in cortex. In the rat whisker system, each whisker is represented by an individual cortical (barrel) column. Here, we quantified in awake, head-fixed rats the impact of natural whisker movements on action potential frequencies of single (identified) neurons located in different layers of somatosensory (barrel) cortex. In all layers, we found only weak correlations between spiking and whisker position or velocity. Conversely, whisking significantly increased spiking rate in a subset of neurons located preferentially in layer 5A. This finding suggests that whisker movement could be encoded by population responses of neurons within all layers and by single slender-tufted pyramids in layer 5A.