THE ASSOCIATION OF INDIVIDUAL ALLERGEN REACTIVITY WITH RESPIRATORY-DISEASE IN A NATIONAL SAMPLE - DATA FROM THE 2ND NATIONAL-HEALTH AND NUTRITION EXAMINATION SURVEY, 1976-80 (NHANES-II)
THE ASSOCIATION OF INDIVIDUAL ALLERGEN REACTIVITY WITH RESPIRATORY-DISEASE IN A NATIONAL SAMPLE - DATA FROM THE 2ND NATIONAL-HEALTH AND NUTRITION EXAMINATION SURVEY, 1976-80 (NHANES-II)
复制标题
DOI：
10.1016/0091-6749(92)90130-t
复制
发表时间：
1992-10-01
影响因子：
14.2
通讯作者：
TURKELTAUB, PC
中科院分区：
文献类型：
--
作者：
GERGEN, PJ;TURKELTAUB, PC
使用第二次全国健康和营养检查调查，评估了个体过敏原反应性与呼吸系统疾病的独立相关性。第二次全国健康和营养检查调查以6至24岁的美国白人平民为样本(n=4295)。8只，1：20重量/体积，50%甘油，非标准提取物，用针刺法给药。过敏原反应性是指20分钟时红斑平均直径10.5 mm或更大的百分比。只有哮喘和过敏性鼻炎的患病率随着过敏原皮肤测试阳性次数的增加而增加。个体过敏原反应性与呼吸道疾病的独立相关性通过Logistic模型进行量化，该模型包括其他过敏原反应性、年龄、性别、吸烟和地区。哮喘与对房屋灰尘的反应性(优势比，2.9；95%可信区间[CI]1.7至5)和交链孢霉(优势比，5.1；95%可信区间：2.9至8.9)相关。过敏性鼻炎与对豚草(优势比，2.3；95%CI：1.5至3.3)、黑麦草(优势比，2.8；95%CI：1.8至4.3)、屋尘(优势比，2.5；95%CI：1.6至3.9)、交链孢属(优势比，2.3；95%CI：1.5至3.4)的反应性有关。只有哮喘(没有过敏性鼻炎)与粉尘和交链孢霉有关。只有过敏性鼻炎(没有哮喘)与黑麦草、豚草和房屋灰尘有关。当哮喘和过敏性鼻炎都存在时，只有屋尘和交链孢子菌仍有关联。这些发现突出了特定过敏原与上呼吸道和下呼吸道疾病的关联以及共存的呼吸道疾病之间的相互作用。
The independent association of individual allergen reactivity with respiratory disease was evaluated with use of the second National Health and Nutrition Examination Survey, a sample of the U.S. white civilian population, ages 6 to 24 years (n = 4295). Eight, 1:20 wt/vol, 50% glycerol, unstandardized extracts were administered by prick puncture. Allergen reactivity was reported as the percent with a mean erythema diameter 10.5 mm or greater at 20 minutes. Only the prevalence of asthma and allergic rhinitis increased with the increasing number of positive allergen skin tests. The independent association of individual allergen reactivity with respiratory disease was quantified with logistic models that included other allergen reactivity, age, sex, smoking, and region. Asthma was associated with reactivity to house dust (odds ratio, 2.9; 95% confidence interval [CI] 1.7 to 5) and Alternaria (odds ratio, 5.1; 95% CI: 2.9 to 8.9). Allergic rhinitis was associated with reactivity to ragweed (odds ratio, 2.3; 95% CI: 1.5 to 3.3); ryegrass (odds ratio, 2.8; 95% CI: 1.8 to 4.3); house dust (odds ratio, 2.5; 95% CI: 1.6 to 3.9); Alternaria (odds ratio, 2.3; 95% CI: 1.5 to 3.4). Asthma only (without allergic rhinitis) was associated with dust and Alternaria. Allergic rhinitis only (without asthma) was associated with ryegrass, ragweed, and house dust. When both asthma and allergic rhinitis were present, only house dust and Alternaria remained associated. These findings highlight the association of specific allergens with upper and lower respiratory diseases and the interactions among coexisting respiratory diseases.