The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb
The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb
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DOI：
10.1016/j.fsigen.2017.11.009
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发表时间：
2018-03-01
影响因子：
3.1
通讯作者：
Ropero-Miller, Jeri D.
中科院分区：
文献类型：
--
作者：
Kidd, Kenneth K.;Soundararajan, Usha;Ropero-Miller, Jeri D.
2011年推出了遗传学知识库法证资源/参考资料网站<https://frog.med.yale.edu/FrogKB/>，自上一份出版物发表以来的五年里，对数据库如何更好地为法证服务的持续研究导致对数据库界面和功能进行了广泛的重新设计。FROG-kb最初被设计为支持法医使用单核苷酸多态性（SNP）的原型，它提供了一个免费访问的Web界面，方便法医实践，并可用于教学和研究。根据使用过程中获得的知识，重新设计了网络界面，以便更容易地浏览多个组成部分。该网站还具有功能增强，广泛的新文档，以及新的SNP参考面板和新的策划数据。FROG-kb专注于单核苷酸多态性（SNP），并为几个已发表的个体识别SNP（IISNP）和几个已发表的祖先推断SNP（AISNP）提供参考人群数据。对于具有参考群体数据的各种标记物组中的每一个，FROG-kb计算用户输入的基因型谱（完全或部分指定）的随机匹配概率（RMP）和祖先的相对可能性。可获得基因型图谱示例，用户手册提供了计算的解释指南。广泛的文档沿着不断更新，使FROG-kb成为促进SNPs在法医实践和教育中使用的综合工具。这里介绍了新的FROG-kb的概述，并提供了解释其使用结果的示例和材料。
The Forensic Resource/Reference on Genetics-knowledge base (FROG-kb) web site < https://frog.med.yale.edu/FrogKB/> was introduced in 2011 and in the five years since the previous publication ongoing research into how the database can better serve forensics has resulted in extensive redesign of the database interface and functionality. Originally designed as a prototype to support forensic use of single nucleotide polymorphisms (SNPs), FROG-kb provides a freely accessible web interface that facilitates forensic practice and can be useful for teaching and research. Based on knowledge gained through its use, the web interface has been redesigned for easier navigation through the multiple components. The site also has functional enhancements, extensive new documentation, and new reference panels of SNPs with new curated data. FROG-kb focuses on single nucleotide polymorphisms (SNPs) and provides reference population data for several published panels of individual identification SNPs (IISNPs) and several published panels of ancestry inference SNPs (AISNPs). For each of the various marker panels with reference population data, FROG-kb calculates random match probabilities (RMP) and relative likelihoods of ancestry for a user-entered genotype profile (either completely or partially specified). Example genotype profiles are available and the User's Manual presents interpretation guidelines for the calculations. The extensive documentation along with ongoing updates makes FROG-kb a comprehensive tool in facilitating use of SNPs in forensic practice and education. An overview of the new FROG-kb with examples and material explaining the results of its use are presented here.