The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update
The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update
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DOI：
10.1177/0961203310381774
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发表时间：
2011-01-01
期刊：
影响因子：
2.6
通讯作者：
Lee, Y. H.
中科院分区：
文献类型：
--
作者：
Lea, W. W.;Lee, Y. H.
本研究的目的是确定功能性蛋白酪氨酸磷酸酶非受体22 (PTPN22) C1858T多态性（rs2476601）是否与不同种族人群对系统性红斑狼疮（SLE）的易感性有关。对11项比较研究的PTPN22 C1858T多态性进行meta分析。meta分析显示，所有研究对象中PTPN22 1858T等位基因与SLE存在相关性（优势比（OR） 1.560, 95%可信区间（CI） 1.336, 1.822, p = 2.0 × 10(-8)）。种族分层后的分析表明，PTPN22 1858T等位基因与欧洲人和西班牙人的SLE显著相关(OR 1.490, 95% CI 1.280, 1.735, p = 2.0 × 10(-8)；OR 2.355, 95% CI 1.644, 3.373, p = 2.9 × 10(-6))。荟萃分析显示，C/T+T/T基因型与所有研究对象、欧洲人和西班牙人的SLE易感性相关，并且T/T基因型与欧洲人的SLE之间存在关联。非裔美国人的T等位基因患病率（2.2%）远低于其他研究人群，而欧洲人的发病率最高（9.5%）。综上所述，本荟萃分析证实PTPN22 C1858T多态性与不同种族的SLE易感性相关，且其患病率与种族相关。狼疮（2011）20,51 -57。
The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across 11 comparative studies. Meta-analysis showed an association between the PTPN22 1858T allele and SLE in all study subjects (odds ratio (OR) 1.560, 95% confidence interval (CI) 1.336, 1.822, p = 2.0 x 10(-8)). Analysis after stratification by ethnicity indicated that the PTPN22 1858T allele was significantly associated with SLE in Europeans and Hispanics (OR 1.490, 95% CI 1.280, 1.735, p = 2.0 x 10(-8); OR 2.355, 95% CI 1.644, 3.373, p = 2.9 x 10(-6)). The meta-analysis showed that the C/T+T/T genotype was associated with susceptibility to SLE in all study subjects, Europeans, and Hispanics populations, and an association between the T/T genotype with SLE in Europeans. African Americans had a much lower prevalence of the T allele (2.2%) than any other population studied, and Europeans had the highest frequency (9.5%). In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. Lupus (2011) 20, 51-57.