18F-florbetaben Aβ imaging in mild cognitive impairment
18F-florbetaben Aβ imaging in mild cognitive impairment
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DOI：
10.1186/alzrt158
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发表时间：
2013-01-01
影响因子：
9
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
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作者：
Ong, Kevin;Villemagne, Victor L.;Rowe, Christopher C.
前言：采用F-18-氟倍他滨和正电子发射断层扫描技术，研究轻度认知损害(MCI)患者的β-淀粉样蛋白(Aβ)沉积与认知功能、海马体体积和脑白质高信号的关系。使用新皮质标准摄取值比率阈值>；=1.45来区分高Aβ负荷和低Aβ负荷。调整了年龄、性别和教育年限的相关性。结果：53%的MCI患者存在高Aβ负荷。回归分析显示，标准化摄取值比率(r=-0.51，P=0.0015)和海马体体积(r=0.6，P=0.024)均独立地影响情景记忆损害。脑白质高信号与非记忆认知相关，尤其与Aβ负荷相关。结论：MCI中高Aβ沉积与更严重的记忆损害有关，并与早期遗忘性症状无关的海马区萎缩有关。
Introduction: F-18-florbetaben and positron emission tomography were used to examine the relationships between beta-amyloid (A beta) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold >= 1.45 was used to discriminate high from low A beta burden. Correlations were adjusted for age, gender and years of education.Results: High A beta burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with A beta burden.Conclusion: Higher A beta deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.