Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
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发表时间：
2002-11
期刊：
影响因子：
11.2
通讯作者：
T. Oka;M. Ouchida;M. Koyama;Y. Ogama;S. Takada;Yoko Nakatani;Takehiro Tanaka;T. Yoshino;K. Hayashi;N. Ohara;E. Kondo;Kiyoshi Takahashi;J. Tsuchiyama;M. Tanimoto;K. Shimizu;T. Akagi
中科院分区：
文献类型：
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作者：
T. Oka;M. Ouchida;M. Koyama;Y. Ogama;S. Takada;Yoko Nakatani;Takehiro Tanaka;T. Yoshino;K. Hayashi;N. Ohara;E. Kondo;Kiyoshi Takahashi;J. Tsuchiyama;M. Tanimoto;K. Shimizu;T. Akagi
在各种白血病和淋巴瘤以及许多造血细胞系中检测到造血细胞特异性蛋白酪氨酸磷酸酶SHP1基因通过启动子甲基化而高频沉默，这得到了我们之前观察到的SHP1 mRNA和蛋白强烈减少的支持。 SHP1基因启动子甲基化与临床分期明显相关。 79% 的急性淋巴细胞白血病病例显示 SHP1 基因附近微卫星标记杂合性丢失。这些结果表明 SHP1 的功能丧失与白血病/淋巴瘤的发病机制有关。
High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.