Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development
Zebrafish E-cadherin: Expression during early embryogenesis and regulation during brain development
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DOI：
10.1002/dvdy.1132
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发表时间：
2001-06-01
影响因子：
2.5
通讯作者：
Marrs, JA
中科院分区：
文献类型：
--
作者：
Babb, SG;Barnett, J;Marrs, JA
克隆了斑马鱼E-钙粘蛋白（cdh 1）细胞粘附分子cDNA。我们研究了cdh 1在早期胚胎发生过程中的时空表达。在卵裂球、原肠胚形成过程中的前中胚层和发育中的上皮结构中观察到表达。在发育中的神经系统中，cdh 1在咽期（24 hpf）在中脑-后脑边界（MHB）中检测到，发育。MHB形成的调节涉及wnt 1和pax2.1。在MHB形成过程中，wnt 1的表达先于cdh 1的表达，而cdh 1在MHD中的表达依赖于该结构的正常发育。(C)2001 Wiley-Liss，Inc.
Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB), Developmental. regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHD was dependent on normal development of this structure. (C) 2001 Wiley-Liss, Inc.