THE AMERICAN-COLLEGE-OF-RHEUMATOLOGY 1990 CRITERIA FOR THE CLASSIFICATION OF CHURG-STRAUSS-SYNDROME (ALLERGIC GRANULOMATOSIS AND ANGIITIS)
THE AMERICAN-COLLEGE-OF-RHEUMATOLOGY 1990 CRITERIA FOR THE CLASSIFICATION OF CHURG-STRAUSS-SYNDROME (ALLERGIC GRANULOMATOSIS AND ANGIITIS)
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DOI：
10.1002/art.1780330806
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发表时间：
1990-08-01
影响因子：
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通讯作者：
ZVAIFLER, NJ
中科院分区：
文献类型：
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作者：
MASI, AT;HUNDER, GG;ZVAIFLER, NJ
通过将20例诊断为Churg - Strauss综合征（CSS）的患者与787例患有其他形式血管炎的对照患者进行比较，制定了CSS的分类标准。对于传统形式的分类，选择了6个标准：哮喘，嗜酸性粒细胞增多，白细胞计数差异10%，单神经病变（包括多发性）或多神经病变，x线摄影非固定肺浸润，鼻窦异常，活检含有血管外嗜酸性粒细胞的血管。这6项标准中的4项或以上的存在产生了85%的敏感性和99.7%的特异性。根据3个选择的标准构建分类树：哮喘、嗜酸性粒细胞增生（白细胞计数差异为10%）、除哮喘或药物敏感性外有过敏史。如果受试者患有嗜酸性粒细胞增多症，并有哮喘或过敏史，则该受试者被归类为患有CSS。树型分类的敏感性为95%，特异性为99.2%。本文讨论了传统格式与分类树格式在应用于全身性血管炎患者时的优势，以及与早期CSS工作的比较。
Criteria for the classification of Churg‐Strauss syndrome (CSS) were developed by comparing 20 patients who had this diagnosis with 787 control patients with other forms of vasculitis. For thetraditional format classification, 6 criteria were selected: asthma, eosinophilia >10% on differential white blood cell count, mononeuropathy (including multiplex) or polyneuropathy, non‐fixed pulmonary infiltrates on roentgenography, paranasal sinus abnormality, and biopsy containing a blood vessel with extravascular eosinophils. The presence of 4 or more of these 6 criteria yielded a sensitivity of 85% and a specificity of 99.7%. Aclassification treewas also constructed with 3 selected criteria: asthma, eosinophilia >10% on differential white blood cell count, and history of documented allergy other than asthma or drug sensitivity. If a subject has eosinophilia and a documented history of either asthma or allergy, then that subject is classified as having CSS. For the tree classification, the sensitivity was 95% and the specificity was 99.2%. Advantages of the traditional format compared with the classification tree format, when applied to patients with systemic vasculitis, and their comparison with earlier work on CSS are discussed.