Phase-shift, stimuli-responsive drug carriers for targeted delivery.
Phase-shift, stimuli-responsive drug carriers for targeted delivery.
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DOI：
10.4155/tde.11.81
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发表时间：
2011-09
影响因子：
4.2
通讯作者：
Rapoport N
中科院分区：
文献类型：
--
作者：
O'Neill BE;Rapoport N
粒子和定向能的交叉是一种新颖而有用的技术的丰富来源，直到最近才被实现用于医学。最有前途的应用之一是定向药物递送。这篇评论的重点是相移纳米粒子（即，亚微米尺寸的颗粒）以及微米级的颗粒，其行动取决于外部能量触发，一阶相移从液体到气体状态的颗粒本身或周围介质。这些颗粒具有巨大的潜力，可以主动破坏它们的环境，从而改变运输特性和卸载药物。本文综述了超声和激光激活的相移纳米和微米粒子及其在药物输送中的应用。基于相移的药物输送机制和竞争技术进行了讨论。
The intersection of particles and directed energy is a rich source of novel and useful technology that is only recently being realized for medicine. One of the most promising applications is directed drug delivery. This review focuses on phase-shift nanoparticles (that is, particles of submicron size) as well as micron-scale particles whose action depends on an external-energy triggered, first-order phase shift from a liquid to gas state of either the particle itself or of the surrounding medium. These particles have tremendous potential for actively disrupting their environment for altering transport properties and unloading drugs. This review covers in detail ultrasound and laser-activated phase-shift nano- and micro-particles and their use in drug delivery. Phase-shift based drug-delivery mechanisms and competing technologies are discussed.