Biological roles of cyclic-nucleotide-gated ion channels in plants: What we know and don't know about this 20 member ion channel family
Biological roles of cyclic-nucleotide-gated ion channels in plants: What we know and don't know about this 20 member ion channel family
复制标题
DOI：
10.1139/b08-147
复制
发表时间：
2009-07-01
期刊：
影响因子：
1.1
通讯作者：
Yoshioka, Keiko
中科院分区：
文献类型：
--
作者：
Chin, Kimberley;Moeder, Wolfgang;Yoshioka, Keiko
环核苷酸门控离子通道（CNGC）是一种非选择性的阳离子通道，首先在脊椎动物视网膜光感受器和嗅觉感觉神经元中发现。CNGC在动物中的作用是有据可查的，并且它们被认为作为异源四聚体定位于质膜。到目前为止，在哺乳动物基因组中仅发现了6个CNGC基因（CNGA 1 -4，CNGB 1和CNGB 3）。而拟南芥（Arabidopsis thaliana（L.）嘿基因组编码20个推定的CNGC亚基，这些亚基被认为以与动物亚基相同的四聚体形式组装。虽然拟南芥CNGC的研究仍处于起步阶段，但目前的研究揭示了它们转运阳离子的能力，这些阳离子在介导各种生物和非生物胁迫和发育过程中发挥作用。这篇综述讨论了目前的知识，植物CNGCs和功能方面的重点，参考异源表达研究和反向遗传学分析。此外，这些渠道的结构方面进行了讨论。
Cyclic-nucleotide-gated ion channels (CNGCs) are nonselective cation channels that were first identified in vertebrate retinal photoreceptors and olfactory sensory neurons. The role of CNGCs in animals is well documented, and they are believed to localize to the plasma membrane as heterotetramers. So far, only six CNGC genes (CNGA1-4, CNGB1, and CNGB3) have been identified in mammalian genomes. In contrast, the Arabidopsis thaliana (L.) Heynh. genome encodes 20 putative CNGC subunits that are thought to assemble in the same tetrameric form as animal subunits do. Although the study of Arabidopsis CNGCs is still in its infancy, current research revealed their ability to transport cations that play a role in mediating various biotic and abiotic stresses and developmental processes. This review discusses the current knowledge of plant CNGCs and focuses on functional aspects, with references to heterologous expression studies and reverse genetics analyses. In addition, structural aspects of these channels are discussed.