Ketogenic diet for treatment of infantile spasms
Ketogenic diet for treatment of infantile spasms
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DOI：
10.1016/j.braindev.2006.03.011
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发表时间：
2006-10-01
影响因子：
1.7
通讯作者：
Kim, Heung Dong
中科院分区：
文献类型：
--
作者：
Eun, So Hee;Kang, Hoon Chul;Kim, Heung Dong
本研究旨在评估生酮饮食 (KD) 治疗婴儿痉挛症 (IS) 的功效、耐受性和安全性，并根据我们之前的生酮饮食经验修改了方案。我们对 1995 年 6 月至 2004 年 5 月期间在韩国两个癫痫中心尝试 KD 的 43 名患有灾难性 IS 的儿童进行了回顾性分析。结果测量包括癫痫发作频率、脑电图（EEG）、不良反应和神经发育。总体而言，该饮食使 53.5% (23/43) 的患者达到无癫痫发作状态，并且使 62.8% (27/43) 的患者癫痫发作频率减少 90% 以上。癫痫发作结果与脑电图结果和发展的改善高度一致。此外，由于我们修改后的方案包括初始非禁食饮食、8个月的短期试验、脂质与非脂质比例为3:1的富含蛋白质的饮食以及液体生酮奶，KD可以更安全、更舒适地维持。大多数并发症都是短暂的，并且在大多数情况下 KD 的耐受性良好。 KD 可以成为治疗灾难性 IS 的有效替代疗法，并且未来不断调整饮食可能会带来额外的好处。 (c) 2006 Elsevier B.V. 保留所有权利。
This study sought to evaluate the efficacy, tolerability, and safety of a ketogenic diet (KD) in the treatment of infantile spasms (IS), incorporating a revised protocol based on our previous experience with KD. We undertook a retrospective analysis of 43 children who suffered from catastrophic IS and tried KD from June 1995 to May 2004 in two Korean epilepsy centers. Outcome measures included seizure frequency, electroencephalograms (EEGs), adverse reactions, and neurological development. Overall, the diet achieved the seizure-free state in 53.5% (23/43) of patients and a greater than 90% reduction of seizure frequency in 62.8% (27/43) of patients. The seizure outcomes were highly concordant with improvements in EEG findings and development. In addition, KD could be maintained more safely and more comfortably because of our revised protocol that included an initial non-fasting diet, a short-term trial of 8 months, a more protein-rich diet with a lipid to non-lipid ratio of 3:1, and liquid ketogenic milk. Most complications were transient and KD was well tolerated in most cases. KD can be an effective alternative therapy for catastrophic IS, and additional benefits may be derived from constant revision of the diet in the future. (c) 2006 Elsevier B.V. All rights reserved.