Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population
Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population
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miR-146a基因多态性与中国中南部人群鼻咽癌风险的关系
DOI：
10.1038/jhg.2013.135
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发表时间：
2014-03-01
影响因子：
3.5
通讯作者：
He, Zhiwei
中科院分区：
文献类型：
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作者：
Huang, Guo-Liang;Chen, Mei-Ling;He, Zhiwei
本病例对照研究的重点是估计miR-146a多态性与中国中南部鼻咽癌（NPC）风险之间的关系。采用聚合酶链反应-限制性片段长度多态性测定法对中国中南部地区160例鼻咽癌患者和200例健康对照进行基因分型。采用卡方检验评估miR-146a多态性在鼻咽癌患者和对照组之间的分布差异；采用logistic回归分析不同对比模型中miR-146a多态性与癌症风险的关系。鼻咽癌患者与对照组在基因型上存在显著差异（GG vs CG vs CC），优势比(OR)= 0.568, 95%可信区间(CI)= 0.354 ~ 0.912， P= 0.019；CG与CC的OR= 0.503, 95% CI= 0.261 ~ 0.971， P= 0.041；GG+ CG与CC的OR= 0.564, 95% CI= 0.360-0.884， P= 0.012)和等位基因分析（G与C的P= 0.025）。我们的研究结果表明，在中国中南部人群中，mir-146a多态性与鼻咽癌有关。
This case-control study focused on estimating the association between miR-146a polymorphism and risk of nasopharyngeal carcinoma (NPC) in central-south China. In total, 160 patients with NPC and 200 healthy controls in central-south China were genotyped using polymerase chain reaction–restriction fragment length polymorphism assay. Chi-square test was used to assess the different distribution of miR-146a polymorphism between NPC patients and controls; and logistic regression analysis was applied to analyze the associations between miR-146a polymorphism with cancer risk in different contrast models. Significant differences between NPC patients and controls were found in genotype (P= 0.033 for GG versus CG versus CC; and odds ratio (OR)= 0.568, 95% confidence interval (CI)= 0.354–0.912, P= 0.019 for CG versus CC; and OR= 0.503, 95% CI= 0.261–0.971, P= 0.041 for CG versus CC; and OR= 0.564, 95% CI= 0.360–0.884, P= 0.012 for GG+ CG versus CC, respectively) and allelic analysis (P= 0.025 for G versus C). Our findings suggested that polymorphism of mir-146a was associated with NPC in the central-southern Chinese population.