MEASUREMENT OF UPPER ESOPHAGEAL SPHINCTER PRESSURE - EFFECT OF ACUTE EMOTIONAL-STRESS
MEASUREMENT OF UPPER ESOPHAGEAL SPHINCTER PRESSURE - EFFECT OF ACUTE EMOTIONAL-STRESS
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DOI：
10.1016/0016-5085(87)90915-2
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发表时间：
1987-09-01
期刊：
影响因子：
29.4
通讯作者：
COLLINS, SM
中科院分区：
文献类型：
--
作者：
COOK, IJ;DENT, J;COLLINS, SM
最近的研究表明，静息的上食道括约肌压力比之前认为的更不稳定，在快速测压拔管时会增加，在睡眠和麻醉时显著降低。用测压套筒装置对13名正常人的静息上食道括约肌压力的影响进行了评估。测压侧孔位于咽部和颈、胸段食道，而袖状感受器横跨上食道括约肌。受试者被间歇性地强调了14分钟的二分听力任务。作为激励，提供了经济奖励，并使其与业绩相称。心率、血压和皮肤电导率的变化证实了应激源的有效性。控制期内食道上括约肌的整体平均压力为46.5 mm Hg(扫描电子显微镜=4.7)。在应激期间有显著的平均增加(11.8。+-)。2.9毫米汞柱；P=0.002)，食道上括约肌压力较对照水平增加，在第一个2分钟应激期内压力增加为20.8±-。3.9毫米汞柱(p=0.0003)。在正常受试者中，情绪应激导致上段食道压力显著升高。这种效应可能会影响静息括约肌压力的测量，特别是在测量条件对受试者有压力的情况下。
Recent studies suggest that resting upper esophageal sphincter pressure is more labile than previously thought, being augmented during rapid manometric pull-through and markedly decreased during sleep and anesthesia. The effect of acute emotional stress on resting upper esophageal sphincter pressure was evaluated in 13 normal subjects with a manometric sleeve assembly. Manometric sideholes were positioned in the pharynx and cervical and thoracic esophagus while the sleeve senor straddled the upper esophageal sphincter. Subjects were stressed intermittently by 14-min periods of a dichotic listening task. As incentive, a financial reward was offered and made commensurate with performance. Alterations of heart rate, blood pressure, and skin conductance confirmed the effectiveness of the stressor. The overall mean upper esophageal sphincter pressure during control periods was 46.5 mmHg (SEM = 4.7). During stress there was a significant mean increase (11.8 .+-. 2.9 mmHg; p = 0.002) in upper esophageal sphincter pressure from control levels, and the pressure increase during the first 2-min epoch of stress was 20.8 .+-. 3.9 mmHg (p = 0.0003). Emotional stress causes significant elevation of upper esophageal pressure in normal subjects. This effect is likely to influence resting sphincter pressure measurements, particularly if measurement conditions are stressful to the subject.