Slow and Rapid Psychobiological Alterations in a Manic-depressive Patient: Clinical Phenomenology
Slow and Rapid Psychobiological Alterations in a Manic-depressive Patient: Clinical Phenomenology
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躁狂抑郁症患者缓慢和快速的心理生物学变化：临床现象学
DOI：
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发表时间：
1977
影响因子：
10.5
通讯作者：
W. Bunney
中科院分区：
文献类型：
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作者：
F. Stoddard;R. Post;W. Bunney
摘要：在快速循环的躁狂抑郁症患者中，在8个情感发作期间报告了一种独特的临床变化模式。在快速切换到接近最大强度的情感症状后，症状学的缓慢变化通过每次发作过程中的显著斜率和相关系数来记录。抑郁、焦虑、困倦、无助/绝望、愤怒和悲伤在转变为躁狂之前有所减少；在转变为抑郁之前，狂躁、兴奋、寻求他人和交谈的减少。重要的心理事件似乎经常先于快速的情绪转变。这表明，在情感发作期间发生的持续缓慢的临床变化可能反映了潜在的节律性生物过程的一部分，环境事件可能能够触发脆弱时期情绪转换的最终共同途径。
Summary A distinctive pattern of clinical change during eight affective episodes is reported in a rapidly cycling manic-depressive patient. After a rapid switch to near maximal intensity of affective symptoms, slow changes in symptomatology were documented by significant slopes and correlation coefficients over the course of each episode. Decreases in depression, anxiety, drowsiness, helplessness/hopelessness, anger, and sadness preceded the switches into mania; decreases in mania, euphoria, seeking others, and talking preceded the switches into depression. Psychologically important events appeared to regularly precede rapid mood switches. It is suggested that the consistent, slow clinical changes which occur during affective episodes may reflect part of an underlying rhythmic biological process and that environmental events may be capable of triggering a final common pathway for the mood switch during a vulnerable period.