IMMUNOLOGICAL INVOLVEMENT IN THE PATHOGENESIS OF PRISTANE-INDUCED ARTHRITIS
IMMUNOLOGICAL INVOLVEMENT IN THE PATHOGENESIS OF PRISTANE-INDUCED ARTHRITIS
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DOI：
10.1111/j.1365-3083.1987.tb02205.x
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发表时间：
1987-04-01
影响因子：
3.7
通讯作者：
HINTON, CE
中科院分区：
文献类型：
--
作者：
BEDWELL, AE;ELSON, CJ;HINTON, CE
实验结果表明，2，6，10，14-四甲基十五烷（降植烷）诱导的小鼠关节炎的发生与免疫反应有关。小鼠在注射降植烷前接受500拉德的辐射，没有发生关节炎。相比之下，给予正常供体淋巴细胞并用降植烷激发的受辐射小鼠出现关节炎。其他实验表明，接受降植烷照射的小鼠的淋巴细胞抑制了接受降植烷攻击的小鼠关节炎的发展。最后，给予降植烷的CBA/Igb小鼠的关节炎发病率显著高于同种异型同源品系CBA/H，这表明与重链免疫球蛋白位点相关的基因控制关节炎的发展。
Evidence is presented that the development of arthritis induced mice by 2,6,10,14-tetramethylpentadecane (pristane) involves the immune response. Mice irradiated (500 rad) before injection of pristane failed to develop arthritis. By contrast, irradiated mice given lymphoid cells from normal donors and challenged with pristane developed arthritis. Other experiments showed that lymphoid cells from irradiated mice given pristane suppressed the development of arthritis in recipients challenged from pristane. Finally, the incidence of arthritis was significantly higher in CBA/Igb mice given pristane than in the allotypic congenic strain CBA/H, suggesting that a gene linked to the heavy chain immunoglobulin locus controls the development of arthritis.