Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines.
Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines.
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DOI：
10.1186/s12951-017-0319-9
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发表时间：
2017-11-17
影响因子：
10.2
通讯作者：
Burkhart DJ
中科院分区：
文献类型：
--
作者：
De Serrano LO;Burkhart DJ
疫苗学是现代医学最重要的基石之一，可以提供更好的生活质量。人类免疫系统由先天性免疫过程和适应性免疫过程组成，在感染发生时相互作用。先天免疫依赖于病原体相关的分子模式，这些分子模式被位于抗原呈递细胞中的病原体识别受体识别。抗原加工和呈递后，CD4+ T 细胞发生极化，进一步导致 B 细胞和 CD8+ 激活以及体液和细胞介导的适应性免疫反应。脂质体被用作疫苗技术，其设计对于确保适当的免疫反应非常重要。必须完全了解脂质体大小、电荷、层状和双层流动性等物理化学参数，以确保最佳的疫苗稳定性和功效。可以开发脂质体疫苗来针对特定的免疫细胞类型，以诱导某些免疫反应。在这篇综述中，我们将提出有前景的脂质体疫苗方法，用于治疗重要的病毒、细菌、真菌和寄生虫感染（包括结核病、结核病）。阳离子脂质体是研究最多的脂质体类型，因为它们与带负电的免疫细胞的相互作用增强。因此，还专门介绍了阳离子脂质二甲基双十八烷基铵和 TB。
Vaccinology is one of the most important cornerstones in modern medicine, providing better quality of life. The human immune system is composed of innate and adaptive immune processes that interplay when infection occurs. Innate immunity relies on pathogen-associated molecular patterns which are recognized by pathogen recognition receptors localized in antigen presenting cells. After antigen processing and presentation, CD4+ T cell polarization occurs, further leading to B cell and CD8+ activation and humoral and cell-mediated adaptive immune responses. Liposomes are being employed as vaccine technologies and their design is of importance to ensure proper immune responses. Physicochemical parameters like liposome size, charge, lamellarity and bilayer fluidity must be completely understood to ensure optimal vaccine stability and efficacy. Liposomal vaccines can be developed to target specific immune cell types for the induction of certain immune responses. In this review, we will present promising liposomal vaccine approaches for the treatment of important viral, bacterial, fungal and parasitic infections (including tuberculosis, TB). Cationic liposomes are the most studied liposome types due to their enhanced interaction with the negatively charged immune cells. Thus, a special section on the cationic lipid dimethyldioctadecylammonium and TB is also presented.
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影响因子：
5.4
作者：
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通讯作者：
Jiskoot W
影响因子：
5.4
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