Gender does not influence sympathetic neural reactivity to stress in healthy humans
Gender does not influence sympathetic neural reactivity to stress in healthy humans
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DOI：
10.1152/ajpheart.1996.270.1.h350
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发表时间：
1996-01-01
影响因子：
4.8
通讯作者：
Ravussin, E
中科院分区：
文献类型：
--
作者：
Jones, PP;Spraul, M;Ravussin, E
先前的数据支持男性交感神经介导的心血管反应增强的观点。然而，由于报告不一致，无法得出明确的结论，这可能是由于交感神经活动测量不精确和/或未能将两性之间的压力刺激等同起来。目前的研究验证了这样一种假设，即男性表现出与心血管和血浆儿茶酚胺反应增强相关的交感神经反应增强。在37名健康成人（20名男性，17名女性，年龄= 20-42岁）中，测量了骨骼肌交感神经活动（MSNA）、血浆儿茶酚胺、心率、血压和感知应激在三个实验室应激源（等长握力、冷压和心算）之前和期间的直接记录。MSNA、儿茶酚胺和心血管反应性（定义为休息后的变化）在性别之间没有一致的差异。对于等距握力，当以绝对单位变化表示时，男性的MSNA响应更大（P < 0.01），其部分原因是收缩力更大；他们在基线变化百分比或感知压力方面没有差异。对冷压机和心算任务的反应在性别之间是相似的。这些发现表明，压力引起的血管收缩神经兴奋和相关的血压升高并不总是受到性别的影响。
Previous data support the idea of heightened sympathetically mediated cardiovascular reactivity in males. However, definitive conclusions cannot be made because of inconsistent reports, possibly stemming from imprecise measurement of sympathetic activity and/or failure to equate the stress stimuli between genders. The present study tested the hypothesis that males exhibit heightened sympathetic reactivity that is associated with heightened cardiovascular and plasma catecholamine responses. In 37 healthy adults (20 males, 17 females: age = 20-42 yr), direct recordings of skeletal muscle sympathetic nerve activity (MSNA), plasma catecholamines, heart rate, blood pressure, and perceived stress were measured before and during three laboratory stressors (isometric handgrip, cold presser, and mental arithmetic). MSNA, catecholamine, and cardiovascular reactivity (defined as change from rest) were not consistently different between genders. For the isometric handgrip, when expressed as absolute unit changes, males had larger MSNA responses (P < 0.01), which were partially explained by greater contraction force; they did not differ in terms of percent change from baseline or in perceived stress. The responses to the cold presser and mental arithmetic tasks were similar between genders. These findings indicate that stress-evoked vasoconstrictor neural excitation and the associated increases in blood pressure are not consistently influenced by gender.