Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32
Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32
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DOI：
10.1021/np2008335
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发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Huang, Hongbo;Yang, Tingting;Ju, Jianhua
从深海放线菌链霉菌SCSIO LR32中分离得到5个新的C-糖苷类绞股蓝环素类化合物，命名为grincamycins B-F(1-5)和一个已知的绞股蓝环素类抗生素(6)。通过广泛的波谱分析，包括MS、ID和2D核磁共振实验，对这些化合物的结构进行了鉴定。除粉霉素F(5)外，其余化合物对人癌细胞株HepG2、SW-1990、HeLa、NCI-H460、MCF-7和小鼠黑色素瘤细胞株B16均有体外细胞毒作用，IC50值为1.1~31mU·M。
Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and ID and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC50 values ranging from 1.1 to 31 mu M.