Subacute sclerosing panencephalitis (SSPE) in Papua New Guinea: a high incidence in young children
Subacute sclerosing panencephalitis (SSPE) in Papua New Guinea: a high incidence in young children
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巴布亚新几内亚的亚急性硬化性全脑炎（SSPE）：幼儿发病率高
DOI：
10.1017/s0950268800050044
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发表时间：
1992
影响因子：
4.2
通讯作者：
Michael P. Alpers
中科院分区：
文献类型：
--
作者：
K. Lucas;R. Sanders;A. Rongap;T. Rongap;S. Pinai;Michael P. Alpers
总结1988年9月至1991年4月在巴布亚新几内亚（PNG）通过脑脊液（CSF）中高滴度麻疹特异性抗体的证明诊断了87例亚急性硬化性全脑炎（SSPE）。1990年，在所研究的省份，SSPE的年发病率计算为每百万20岁以下的人中有56例，预计1991年这一数字将更高。平均发病年龄为4.9岁，男女比例为1.8：1。在SSPE患者中，免疫球蛋白G占CSF中总蛋白的百分比升高，CSF：血清免疫球蛋白G比例升高。这种疾病在巴布亚新几内亚的戏剧性出现和高频率可能与该国儿童感染麻疹的早期年龄有关。
SUMMARY Eighty-seven cases of subacute sclerosing panencephalitis (SSPE) were diagnosed from September 1988 to April 1991 in Papua New Guinea (PNG), by demonstration of high-titre measles-specific antibodies in cerebrospinal fluid (CSF). For 1990 the annual incidence of SSPE, for the study provinces, was calculated to be 56 cases per million under 20 years of age and it is expected that this figure will be higher in 1991. The mean age of presentation was 4.9 years, with a male to female ratio of 1.8:1. An elevation in the ratio of immunoglobulin G as a percentage of total protein in CSF and an increase in the CSF:serum immunoglobulin G ratio was shown in SSPE patients. The dramatic appearance and high frequency of the disease in PNG might relate to the early age of measles infection encountered in children in this country.