Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria
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DOI：
10.4269/ajtmh.2005.72.581
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发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
Talarmin, A
中科院分区：
文献类型：
--
作者：
Menard, D;Madji, N;Talarmin, A
本文报告了在中非共和国班吉（CAR）进行的一项两阶段研究：首先，我们评估了氯喹（CQ）、磺胺嘧啶-乙胺嘧啶（SP）和阿莫地喹（AQ）的临床疗效，然后我们测试了两种组合的疗效：CQ + SP和AQ + SP。我们使用标准的14- 2002年2月至2004年3月期间，在班吉比较5岁以下儿童急性无并发症恶性疟原虫疟疾的治疗反应。CQ、AQ、SP、CQ + SP和AQ + SP的总体治疗失败率分别为40.9%、20.0%、22.8%、7.2%和0%。这些研究结果表明，卫生部应建议班吉将AQ + SP组合作为一线抗疟药物的所有临时政策，直到中非共和国以低价获得最佳替代治疗，如基于青蒿素排放的联合疗法（ACT）。
This paper reports a two-phase study in Bangui, Central African Republic (CAR): first, we assessed the clinical efficacy to chloroquine (CQ), sulfadoxine-pyrimethamine (SP), and amodiaquine (AQ), then we tested the efficacy of two combinations: CQ + SP and AQ + SP. We used the standard 14-day WHO 2001 protocol to compare therapeutic responses in children under 5 years of age with acute uncomplicated Plasmodium falciparum malaria in Bangui between February 2002 and March 2004. The overall treatment failure rates with CQ, AQ, SP, CQ + SP and AQ + SP were 40.9%, 20.0%, 22.8%, 7.2%, and 0%. These findings suggest that the Ministry of Health should recommend all interim policy with AQ + SP combination as the first-line antimalarial drug in Bangui until best alternative treatments like art emission-based combination therapies (ACTs) become available at low prices in the CAR.