Association of Height Growth in Puberty with Lung Function A Longitudinal Study
Association of Height Growth in Puberty with Lung Function A Longitudinal Study
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DOI：
10.1164/rccm.201802-0274oc
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发表时间：
2018-12-15
影响因子：
24.7
通讯作者：
Henderson, John
中科院分区：
文献类型：
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作者：
Mahmoud, Osama;Granell, Raquel;Henderson, John
基本原理：青春期可能会影响肺功能，但青春期身高增长在肺发育中的确切作用尚不清楚。目的：研究青春期的时间和青春期身高增长的峰值速度与青春期和成年早期肺功能的关系。对英国出生队列中4,772名男性和4名男性5 - 20岁重复身高测量的纵向分析，849名女性进行了身高生长轨迹的特点，并得出青春期年龄和峰值身高速度使用验证SITAR（平移和旋转叠加）模型。这些估计值与使用支气管扩张剂前和使用支气管扩张剂后肺功能测定指标的相关性：使用多变量回归模型对15岁和24岁时的FEV 1、FVC、FEV 1/FVC、FEF 25 -75%进行了研究，该模型针对8岁时的肺功能、测量结果时的身高和年龄以及潜在的混杂因素进行了校正。在24岁时，青春期年龄越晚和峰值流速越大，男性和女性的FEV 1和FVC越高。青春期年龄增加1岁，男性（n = 567）FVC增加263 ml（95%置信区间[CI]，167-360 ml），女性（n = 990）FVC增加100 ml（95% CI，50-150 ml）。对于男性和女性，峰值流速增加1 cm/年分别与FVC增加145 ml（95% CI，56-234 ml）和50 ml（95% CI，2-99 ml）相关。未发现与FEV 1/FVC的关联。结论：青春期身高增长的晚发和更大的峰值速度与年轻成人的FEV 1和FVC增加有关，但没有证据表明青春期肺生长的发育不良。
Rationale: Puberty may influence lung function, but the precise role of pubertal height growth in lung development is unclear.Objectives: To examine associations of timing of puberty and peak velocity of pubertal height growth with lung function in adolescence and early adulthood.Methods: Longitudinal analyses of repeat height measurements from age 5 to 20 years for a British birth cohort with 4,772 males and 4,849 females were conducted to characterize height growth trajectories and to derive pubertal age and peak height velocity using the validated SITAR (SuperImposition by Translation and Rotation) model. Association of these estimates with prebronchodilator and post-bronchodilator spirometry measures: FEV1; FVC; FEV1/FVC; FEF25-75% at age 15 and 24 years were investigated using multivariable regression models adjusted for lung function at age 8 years, height and age at time of outcome measurements, and potential confounders.Measurements and Main Results: Later pubertal age and greater peak velocity were associated with higher FEV1 and FVC at 24 years in both sexes. A 1-year increase in pubertal age was associated with a 263-ml higher FVC (95% confidence interval [CI], 167-360 ml) for males (n = 567) and 100-ml (95% CI, 50-150 ml) higher FVC for females (n = 990). A 1-cm/yr increase in peak velocity was associated with 145-ml (95% CI, 56-234 ml) and 50-ml (95% CI, 2-99 ml) increases in FVC for males and females, respectively. No associations were found with FEV1/FVC.Conclusions: Later onset and greater peak velocity of height growth in puberty are associated with increased FEV1 and FVC in young adults but there was no evidence of dysanapsis of pubertal lung growth.