Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic
Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic
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DOI：
10.1089/088922201750461384
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发表时间：
2001-09-01
影响因子：
1.5
通讯作者：
Carr, JK
中科院分区：
文献类型：
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作者：
Reinis, M;Brucková, M;Carr, JK
我们分析了在捷克共和国传播的HIV-1毒株的遗传多样性。39株分离株的env和gag基因序列片段的系统发育分析显示，这些菌株中的大多数（32/39，82%）为B亚型;其他鉴定的遗传亚型为A、C、F和重组循环形式CRF 01_AE。不与亚型B聚类的分离株几乎完全来自异性传播途径。分子流行病学数据表明，捷克共和国境内有多起HIV-1感染病例，并表明在该国传播的HIV-1毒株的基因模式与在其他欧洲国家发现的模式一致。
We analyzed the genetic diversity of HIV-1 strains circulating in the Czech Republic. Phylogenetic analysis of the env and gag gene sequence fragments from 39 isolates revealed that the majority of these strains (32 of 39, 82%) were of subtype B; other genetic subtypes identified were A, C, F, and recombinant circulating form CRF01_AE. The isolates that did not cluster with subtype B originated almost exclusively from a heterosexual route of transmission. The molecular epidemiological data are suggestive of multiple entry of HIV-1 infection into the Czech Republic and show that the genetic pattern of the HIV-1 strains circulating in this country corresponds to that found in other European countries.