FAILURE OF T-CELL HOMEOSTASIS PRECEDING AIDS IN HIV-1 INFECTION
FAILURE OF T-CELL HOMEOSTASIS PRECEDING AIDS IN HIV-1 INFECTION
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DOI：
10.1038/nm0795-674
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发表时间：
1995-07-01
期刊：
影响因子：
82.9
通讯作者：
FERBAS, J
中科院分区：
文献类型：
--
作者：
MARGOLICK, JB;MUNOZ, A;FERBAS, J
我们和其他人假设，T淋巴细胞的数量通常保持不变，而不受CD4(+)或CD8(+)表型的影响(盲目的T细胞稳态)。在这里，我们确认了感染人类免疫缺陷病毒1型(HIV-1)的同性恋者的T细胞水平基本上是恒定的(尽管CD4(+)T细胞显著下降，CD8(+)T细胞增加)，这些人在血清转换后长达八年的时间里没有感染获得性免疫缺陷综合征(AIDS)。相比之下，发生艾滋病的血清转换者在艾滋病前大约两年内表现出T细胞(CD4(+)和CD8(+))的迅速下降，与血清转换和艾滋病之间的时间无关，这表明体内稳定失败是艾滋病毒疾病进展的一个重要里程碑。鉴于HIV-1感染中T细胞的高周转率，盲目的T细胞稳态可能通过CD8(+)T淋巴细胞吞噬干扰丢失的CD4(+)T细胞的再生而参与HIV的发病。
We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4(+) or CD8(+) phenotype ('blind' T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4(+) T cells and increase in CD8(+) T cells) in homosexual men with incident human immunodeficiency virus, type 1 (HIV-1), infection who remained free of acquired immunodeficiency syndrome (AIDS) for up to eight years after seroconversion. In contrast, seroconverters who developed AIDS exhibited rapidly declining T cells (both CD4(+) and CD8(+)) for approximately two years before AIDS, independent of the time between seroconversion and AIDS, suggesting that homeostasis failure is an important landmark in HIV disease progression. Given the high rate of T-cell turnover in HIV-1 infection, blind T-cell homeostasis may contribute to HIV pathogenesis through a CD8(+) T lymphocytosis that interferes with regeneration of lost CD4(+) T cells.