Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins
Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins
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DOI：
10.1039/p19960002591
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发表时间：
1996-11-07
期刊：
影响因子：
--
通讯作者：
Rea, MD
中科院分区：
文献类型：
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作者：
Boland, GM;Donnelly, DMX;Rea, MD
在铃木反应条件下，钯催化4-氯或4-溴香豆素1-4与芳基硼酸5-13的偶联是获得4-芳基香豆素的有效途径。在改进的铃木反应条件下，使用碘化铜(I)作为共催化剂，用芳基硼酸处理4-三氟甲基磺酰基氧香豆素35-38，也可以得到这些4-芳基香豆素，产率（70-97%）很高。
Palladium-catalysed coupling of the 4-chloro- or 4-bromo-coumarins 1-4 with arylboronic acids 5-13 under the Suzuki reaction conditions constitutes an efficient access to 4-arylcoumarins. These 4-arylcoumarins can also be obtained in good yields (70-97%) by treatment of 4-trifluoromethylsulfonyloxycoumarins 35-38 with arylboronic acids under modified Suzuki reaction conditions, involving the use of copper(I) iodide as a co-catalyst.