Protein NMR - Modern Techniques and Biomedical Applications
Protein NMR - Modern Techniques and Biomedical Applications
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蛋白质 NMR - 现代技术和生物医学应用
DOI：
10.1007/978-1-4899-7621-5_3
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Sauerwein A
中科院分区：
文献类型：
--
作者：
Sauerwein A
弛豫色散核磁共振（NMR）光谱自20世纪50年代以来一直在发展，现在已经发展成为一种非常灵敏和通用的工具，用于在微米至毫秒（µs-ms）的时间尺度上研究化学和构象交换过程。虽然弛豫色散NMR最初是针对小分子设计的，但在硬件、实验设计和同位素标记方面取得重大进展后，它已成为研究生物大分子动力学的一个非常有吸引力的工具。
Relaxation dispersion nuclear magnetic resonance (NMR) spectroscopy has been developed since the 1950s and has now evolved into a very sensitive and versatile tool to study chemical and conformational exchange processes on the micro- to milliseconds (µs–ms) time scale. While relaxation dispersion NMR was originally designed with small molecules in mind, it has become a very attractive tool to also study the dynamics of biological macromolecules, after major advances had been made in hardware, experimental design and isotope labelling.