A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients
A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients
复制标题
DOI：
10.1093/carcin/bgi332
复制
发表时间：
2006-07-01
期刊：
影响因子：
4.7
通讯作者：
Dragani, Tommaso A.
中科院分区：
文献类型：
--
作者：
Manenti, Giacomo;Galbiati, Federica;Dragani, Tommaso A.
小鼠Lrmp和Casc1基因是肺腺瘤易感性1（Pas1）基因座的候选基因，Pas1基因座是肺肿瘤易感性中菌株变异的主要决定因素。这些基因包含编码和非编码单核苷酸多态性（SNP），与小鼠肺肿瘤风险密切相关。对361例肺腺癌（ADCA）患者和327例健康对照者的LRMP和CASC1基因SNPs进行分析，发现LRMP（V141 L和S197 C）和CASC1（R33 S和3个内含子变异）中存在共同的SNPs，均未显示与肺ADCA风险显著相关。然而，在时间依赖性考克斯回归模型中，在校正年龄、性别、吸烟史和临床分期后，LRMP基因Leu变异（V141 L）的携带状态与肿瘤发病时年龄较大的患者的较高死亡率相关
Mouse Lrmp and Casc1 genes are candidates for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumor susceptibility. These genes contain coding and non-coding single nucleotide polymorphisms (SNPs) strongly associated with lung tumor risk in mice. Analysis of LRMP and CASC1 gene SNPs in 361 lung adenocarcinoma (ADCA) patients and 327 healthy controls revealed common SNPs in LRMP (V141L and S197C) and CASC1 (R33S and three intronic variations), and none showed a significant association with lung ADCA risk. However, in the time-dependent Cox regression model, after adjustment for age, gender, smoking history and clinical stage, the carrier status of the Leu variation (V141L) of the LRMP gene was associated with higher mortality in patients with age at tumor onset