Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice
Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice
复制标题
长期接触微囊藻毒素-LR 对小鼠肾脏的影响
DOI：
10.3390/ijerph16245030
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发表时间：
2019-12-02
影响因子：
--
通讯作者：
Yang，Fei
中科院分区：
文献类型：
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作者：
Yi，Xiping;Xu，Shuaishuai;Yang，Fei
微囊藻毒素-LR (MC-LR) 是一种强效肝毒素，但一些研究表明它也可能引起肾毒性。然而，长期口服 MC-LR 引起的肾毒性尚不清楚。本研究的目的是评估长期暴露于 MC-LR 后 MC-LR 对小鼠肾脏的潜在影响。在本研究中，我们首次评估了 6 个月内不同浓度（1、30、60、90 和 120 μg/L）的小鼠饮用水中 MC-LR 的肾毒性。结果显示，与对照组相比，MC-LR治疗组小鼠的肾脏重量和肾脏指数没有改变。此外，肾功能指标显示，MC-LR暴露后血清肌酐（SCr）水平无显着变化。暴露于90和120μg/L MC-LR 3个月后，血尿素氮（BUN）水平显着降低。 120 μg/L MC-LR暴露6个月后BUN水平低于对照组。组织病理学检查显示，暴露于60、90和120 μg/L MC-LR后，肾小体增大，肾小管增宽，间质组织和肾盂有淋巴细胞浸润。因此，我们的结果表明，长期暴露于MC-LR可能是肾损伤的重要风险之一，这将为预防肾损伤提供重要线索。
Microcystin-LR (MC-LR) is a potent hepatotoxin, but a few studies suggested that it might also induce nephrotoxicity. However, nephrotoxicity induced by prolonged oral exposure to MC-LR is unknown. The aim of this study was to evaluate the potential influence of MC-LR on the kidney in mice following chronic exposure to MC-LR. In this study, we evaluated the nephrotoxicity of MC-LR in mice drinking water at different concentrations (1, 30, 60, 90, and 120 μg/L) for 6 months for the first time. The results showed that the kidney weights and the kidney indexes of mice were not altered in the MC-LR treated mice, compared with the control group. In addition, the renal function indicators revealed that the serum creatinine (SCr) levels were not significant changes after exposure to MC-LR. The blood urea nitrogen (BUN) levels were markedly decreased after exposure to 90 and 120 μg/L MC-LR for 3 months. The BUN levels were lower than that of the control group after exposure to 120 μg/L MC-LR for 6 months. The histopathological investigation revealed enlarged renal corpuscles, widened of kidney tubules, and lymphocyte infiltration in the interstitial tissue and the renal pelvis after exposure to 60, 90, and 120 μg/L MC-LR. Consequently, our results suggested that long-term exposure to MC-LR might be one important risk of kidney injury, which will provide important clues for the prevention of renal impairment.