Site-specific metastases of gallbladder adenocarcinoma and their prognostic value for survival: a SEER-based study.
Site-specific metastases of gallbladder adenocarcinoma and their prognostic value for survival: a SEER-based study.
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DOI：
10.1186/s12893-021-01068-8
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发表时间：
2021-01-23
期刊：
影响因子：
1.9
通讯作者：
Tu J
中科院分区：
文献类型：
--
作者：
Yang Y;Tu Z;Ye C;Cai H;Yang S;Chen X;Tu J
胆囊癌是一种罕见但高度恶性的癌症，由于其无症状表现，在诊断时通常进展到转移阶段。本研究旨在分析转移性胆囊腺癌（GBA）发生部位特异性转移的预后价值。使用监测，流行病学和最终结果（SEER）数据库，选择2010年至2016年期间诊断为转移的GBA患者，根据孤立的转移部位（包括肝，肺，骨，脑和远端淋巴结（DL））确定预后。采用Kaplan-Meier法进行生存比较，并建立多因素考克斯回归模型，找出影响生存的独立因素。从SEER数据库中提取了1526例合格患者的数据。孤立性肝转移788例（51.6%），孤立性远处淋巴结转移80例（5.2%），孤立性肺转移45例（2.9%），孤立性骨转移21例（1.4%），孤立性脑转移2例（0.1%），多发性转移590例（38.7%）。单灶与多灶转移患者的生存率差异无统计学意义（P > 0.05）。单纯肺转移或DL转移患者的生存率明显高于单纯骨转移患者（P < 0.05）。多因素分析显示，原发灶手术、化疗与孤立性肝转移或DL转移患者的OS和CSS较好相关。该研究表明，不同的转移部位影响转移性GBA患者的生存结局。高度选择的肝或DL转移患者子集可能从原发部位手术中获益。
Gallbladder cancer is a rare but highly malignant cancer, which often progresses to a metastatic stage when diagnosed because of its asymptomatic manifestation. In this study, we intended to analyze the prognostic value of metastatic gallbladder adenocarcinoma (GBA) with site-specific metastases. Using the Surveillance, Epidemiology, and End Results (SEER) database, GBA patients diagnosed with metastases between 2010 and 2016 were selected to identify the prognosis according to the isolated metastatic sites, including liver, lung, bone, brain and distant lymph nodes (DL). Kaplan–Meier methods were used for survival comparisons and multivariable Cox regression models were constructed to find out independent factors that associated with survival. Data from 1526 eligible patients were extracted from the SEER database. Among the patients, 788 (51.6%) had isolated liver metastases, 80 (5.2%) had isolated distant nodal involvement, 45 (2.9%) had isolated lung metastases, 21 (1.4%) had isolated bone metastases, 2 (0.1%) had isolated brain metastases and 590 (38.7%) had multiple metastases. No significant survival difference was shown between patients with single or multisite metastases (P > 0.05). Patients with isolated lung or DL metastases had significant better survival outcomes than those with isolated bone metastases (P < 0.05). Multivariate analysis showed that performing surgery at primary site, receiving chemotherapy were associated with better OS and CSS for patients with isolated liver or DL metastases. The study showed that different metastatic sites affect survival outcomes in metastatic GBA patients. Highly selected subset of patients with liver or DL metastases might benefit from surgery at primary site.
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影响因子：
3.8
作者：
Keutgen XM;Nilubol N;Glanville J;Sadowski SM;Liewehr DJ;Venzon DJ;Steinberg SM;Kebebew E
通讯作者：
Kebebew E
影响因子：
4.3
作者：
Oweira H;Petrausch U;Helbling D;Schmidt J;Mannhart M;Mehrabi A;Schöb O;Giryes A;Decker M;Abdel-Rahman O
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Abdel-Rahman O
影响因子：
2.3
作者：
Huettner, Felix J.;Schneider, Lutz;Ulrich, Alexis
通讯作者：
Ulrich, Alexis
影响因子：
10.3
作者：
Mitin, Timur;Enestvedt, C. Kristian;Sineshaw, Helmneh M.
通讯作者：
Sineshaw, Helmneh M.
DOI：
10.1080/17474124.2021.1864325
发表时间：
2020-12-20
影响因子：
3.9
作者：
Rizzo, Alessandro;Brandi, Giovanni
通讯作者：
Brandi, Giovanni