Arsenic in cancer treatment: challenges for application of realgar nanoparticles (a minireview).
Arsenic in cancer treatment: challenges for application of realgar nanoparticles (a minireview).
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DOI：
10.3390/toxins2061568
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发表时间：
2010-06
期刊：
影响因子：
4.2
通讯作者：
Sedlák J
中科院分区：
文献类型：
--
作者：
Baláž P;Sedlák J
虽然已经为癌症的治疗做出了密集的努力，但在许多国家，这种疾病仍然是第二大死因。转移性乳腺癌、晚期结肠癌、恶性黑色素瘤、多发性骨髓瘤和其他形式的癌症在大多数情况下仍然是无法治愈的。基因组技术的最新进展使得同时评估基于DNA序列的改变以及拷贝数的增加和丢失成为可能。对多目标方法的要求是从这些研究中出现的共同主题。因此，新的靶向生物和细胞毒剂的组合目前正在多模式治疗方案中进行研究。同样，组合原理也适用于传统中医，因为方剂由几种草药或矿物组成，其中一种代表主要成分，其他药物作为辅助药物，帮助发挥主要成分的作用或促进其传递。在西医中，大约有60种不同的砷制剂被开发出来，并在药理学历史上被使用。在传统中药中，使用了不同形式的矿物砷(雌黄-As2S3、雄黄-As4S4和砷石-三氧化二砷，As_2O_3)，并将雄黄单独包含在中国药典委员会(2005年)认可的22种口服药物中。众所周知，某些形式的矿物质中有很大一部分很难被人体吸收，无法造成全身损害。本文主要综述了硫化砷(雄黄)在体内外治疗各种类型癌症中的应用。
While intensive efforts have been made for the treatment of cancer, this disease is still the second leading cause of death in many countries. Metastatic breast cancer, late-stage colon cancer, malignant melanoma, multiple myeloma, and other forms of cancer are still essentially incurable in most cases. Recent advances in genomic technologies have permitted the simultaneous evaluation of DNA sequence-based alterations together with copy number gains and losses. The requirement for a multi-targeting approach is the common theme that emerges from these studies. Therefore, the combination of new targeted biological and cytotoxic agents is currently under investigation in multimodal treatment regimens. Similarly, a combinational principle is applied in traditional Chinese medicine, as formulas consist of several types of medicinal herbs or minerals, in which one represents the principal component, and the others serve as adjuvant ones that assist the effects, or facilitate the delivery, of the principal component. In Western medicine, approximately 60 different arsenic preparations have been developed and used in pharmacological history. In traditional Chinese medicines, different forms of mineral arsenicals (orpiment—As2S3, realgar—As4S4, and arsenolite—arsenic trioxide, As2O3) are used, and realgar alone is included in 22 oral remedies that are recognized by the Chinese Pharmacopeia Committee (2005). It is known that a significant portion of some forms of mineral arsenicals is poorly absorbed into the body, and would be unavailable to cause systemic damage. This review primary focuses on the application of arsenic sulfide (realgar) for treatment of various forms of cancer in vitro and in vivo.
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影响因子：
4
作者：
Balaz, P.;Choi, W. S.;Dutkova, E.
通讯作者：
Dutkova, E.
影响因子：
3.1
作者：
Bonazzi, Paola;Bindi, Luca;Menchetti, Silvio
通讯作者：
Menchetti, Silvio
影响因子：
3.7
作者：
Drayson, MT;Michell, RH;Brown, G
通讯作者：
Brown, G
影响因子：
3.8
作者：
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通讯作者：
Waalkes, MP
影响因子：
5.8
作者：
LIVERSIDGE, GG;CONZENTINO, P
通讯作者：
CONZENTINO, P